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NCT Number: NCT06785168

Effects of Resistance Training on Sarcopenia in Older Patients With Chronic Heart Failure

The goal of study is to evaluate the effects of an eight-week machine-based resistance training program on managing sarcopenia in older outpatients with chronic heart failure (HF) at Military Hospital 175.

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This study is active but is not currently recruiting participants.

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Key information

Conditions

Sarcopenia in Elderly Atrophy Chronic Heart Failure Muscular Atrophy Nervous System Diseases Neurologic Manifestations Neuromuscular Manifestations Pathological Conditions, Anatomical Pathological Conditions, Signs and Symptoms Sarcopenia Signs and Symptoms

Age range

60 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Military Hospital 175, Ho Chi Minh City, Vietnam

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About this study

The participants will be randomly assigned to two groups: One group received machine-based resistance training (MRT) at the hospital, while the other group received usual care (US). The outcomes will be measured in the participants after 8 weeks including handgrip strength, gait speed, performance on the five-times sit-to-stand test.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Aged ≥ 60 years old
  • Meet the diagnostic criteria of 2019 AWGS2 sarcopenia, can be diagnosed once meeting (1) + (2) or (1) + (3) or (1) + (2) + (3): (1) Appendicular skeletal muscle mass (ASM): dual-energy X-ray absorptiometry (DXA) (male <7.0 kg/m², female <5.4 kg/m²). (2) Muscle strength: handgrip strength (male <28.0 kg, female <18.0 kg). (3) Physical performance: 6-meter walking speed <1.0 m/s.
  • Meet the diagnostic criteria of heart failure following ESC 2021.
  • Clearly understand the content and purpose of the study and sign the informed consent form.

Exclusion criteria

There are contraindications for Exercise Testing in patients with stable heart failure according to ACSM 2022:

  • Early stage after acute coronary syndrome (within the first 2 days)
  • Unstable coronary artery disease
  • Decompensated heart failure
  • Acute venous thrombosis or recent arterial embolism (pulmonary or systemic)
  • Acute myocarditis, pericarditis, endocarditis
  • Aortic dissection of the valve
  • Severe symptomatic aortic stenosis
  • Acute systemic disease or fever
  • Uncontrolled or life-threatening atrial or ventricular arrhythmias (including new-onset atrial fibrillation or flutter)
  • Uncontrolled tachycardia (resting heart rate > 120 beats per minute)
  • Third-degree AV block
  • Uncontrolled diabetes
  • Symptomatic orthostatic hypotension (> 20 mmHg)
  • Gradually increasing fatigue during exercise or dyspnea at rest or with exertion within the past 3-5 days
  • Significant myocardial ischemia at low workloads < 2 METs or 50W
  • Relative contraindications according to ACSM 2022:
  • Weight gain ≥ 1.8 kg in the past 1-3 days
  • Simultaneous use of continuous or intermittent Dobutamine
  • Decrease in blood pressure with exercise
  • NYHA IV heart failure
  • Complex ventricular arrhythmias at rest or with exertion
  • Resting heart rate ≥ 100 bpm when lying down
  • Comorbidities that limit exercise
  • Severe obstructive hypertrophic cardiomyopathy
  • Have participated in a cardiovascular rehabilitation program within the last 6 months
  • Do not agree to participate in the study

Treatment and study plan

Machine-based Resistance Training

Other

The participants will receive HF treatment as prescribed by cardiologists. If participants have any additional medical conditions, their existing medications or treatments should continue. They are also asked to maintain their usual physical activity, exercise routines, and dietary habits, without making changes outside of the study intervention. At the beginning, patients participating in resistance training should complete a pretest of one-repetition maximum (1-RM) to assess muscle strength, which will be used by a professional physical therapist to develop an individualized prescription. The specific movements are as follows: (1) leg press and (2) calf raise by Proxomed Compass 540 (Germany); (3) leg curl, (4) chest press, (5) push up, (6) seated row by HUR machine (US). During the 8 weeks, subjects will train 3 non-consecutive days/week with intensity 30%1-RM to 60% 1-RM, 3 sets/one excercise with 8-12 repetitions.

Other names: M-RT, A

Primary outcomes

  1. The change of muscle strength

    Time frame: Baseline and 8 weeks

    The change of muscle strength will be evaluated using handgrip strength, measured in kilograms. Each hand will be tested twice with a Jamar Hydraulic Hand Dynamometer (USA), and the highest value will be recorded.

Secondary outcomes

  1. The change of the five-times sit-to-stand test

    Time frame: Baseline and 8 weeks

    The five-times sit-to-stand test is timed in seconds. Participants will sit in a chair without armrests, ensuring their back and lower legs are straight, with their arms crossed over their chest. They will then stand up and sit down as quickly as possible. The time is recorded using a stopwatch, beginning when the participants stand for the first time and ending when they sit down for the fifth time.

  2. The change of gait speed

    Time frame: Baseline and 8 weeks

    Gait speed is measured in meters per second. Participants will walk at their usual pace over a 6-meter distance, and gait speed will be calculated using the formula v = s/t, where t is the time in seconds and s is the distance (6 meters).

Sponsors and collaborators

Lead sponsor

Kieu Dang Phuong Nguyen

Other

Registry information

Official study title

Effects of Resistance Training on Sarcopenia in Older Patients With Chronic Heart Failure: A Randomized Controlled Trial

Important dates

Study start
2025
Primary completion
2026
Study completion
2027
First posted
Jan 21, 2025
Registry last updated
Jul 23, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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