Skip to main content
OpenTrials
Completed

NCT Number: NCT05051306

Effects of Resistance Exercise on Metabolic Responses

Healthy young adults will complete three trials in a randomized crossover counter-balanced order, including two different loads of resistance exercise and sedentary control. During each trial, blood samples will be collected.

The investigators hypothesized that high-load and low-load resistance exercise exert similar metabolic responses.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Inflammatory Response

Age range

20 year–30 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

National Taiwan Normal University

Taipei, 162, Taiwan

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age: 20-30
  • Healthy male
  • Without experience of resistance training

Exclusion criteria

  • No acute or chronic musculoskeletal symptoms
  • Smoking
  • Alcohol or drug abuse
  • Fail to conduct resistance exercise

Treatment and study plan

High-load resistance exercise

Other

Subjects in high-load trial performed 4 sets per exercise, 8 repetitions with load of 85%-8RM with 90 sec of rest between sets.

Low-Load Resistance Exercise

Other

Subjects in low-load trial performed 4 sets per exercise, 15 repetitions with load of 45%-8RM with 90 sec of rest between sets.

Primary outcomes

  1. Changes in glucose

    Time frame: 4-hour during each study intervention

    glucose in mg/dL

  2. Changes in insulin

    Time frame: 4-hour during each study intervention

    insulin in mU/L

  3. Changes in TG

    Time frame: 4-hour during each study intervention

    TG mg/dL

  4. Changes in uric acid

    Time frame: 4-hour during each study intervention

    uric acid mg/dL.

Secondary outcomes

  1. Changes in biomarkers of inflammation

    Time frame: 4-hour during each study intervention

    Biomarkers of inflammation will be measured such as IL-10 in pg/mL and IL-6 in pg/mL.

  2. Changes in cortisol

    Time frame: 4-hour during each study intervention

    cortisol in ng/mL

  3. Changes in lactate

    Time frame: 4-hour during each study intervention

    lactate in mmol/L

  4. Changes in complete blood count

    Time frame: 4-hour during each study intervention

    blood cell count in count per µL

  5. Borgs Ratings of Perceived Exertion (RPE)

    Time frame: 1-hour during each exercise intervention

    Borgs RPE is a method of estimating exertion rating, based on a 6 to 20 rating scale (6 being the no exertion at all, 20 being maximal exertion).

  6. Changes in ET-1

    Time frame: 4-hour during each study intervention

    ET-1 in pg/mL

  7. Changes in NO

    Time frame: 4-hour during each study intervention

    NO in µmol/L

  8. Changes in biomarkers of muscle damage

    Time frame: 4-hour during each study intervention

    Biomarkers of muscle damage will be measured such as CK in U/L and LDH in U/L.

  9. Heart rate (HR)

    Time frame: 6-hour during each study intervention

    HR will be measured during each study intervention.

  10. Visual Analogue Scale (VAS) of appetite

    Time frame: 6-hour during each study intervention

    Hunger, fullness, desire to eat, and prospective food consumption will be measured via VAS ratings, based on a 100 mm long scale (0 being "not at all", 100 being "extremely").

  11. Changes in biomarkers of appetite

    Time frame: 4-hour during each study intervention

    Biomarkers of appetite will be measured such as ghrelin in pg/mL and PYY in pg/mL.

Sponsors and collaborators

Lead sponsor

National Taiwan Normal University

Other

Registry information

Official study title

Effects of Volume-matched Resistance Exercise With Different Loads on Metabolic Responses

Important dates

Study start
2021
Primary completion
2021
Study completion
2021
First posted
Sep 21, 2021
Registry last updated
Mar 16, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.