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NCT Number: NCT06606704

Effects of Resistance-band Training and Creatine Supplementation Strategies in Healthy Older Adults

The primary purpose is to compare the effects of creatine supplementation (bolus ingestion of 5 grams vs. 3 grams) during 16 weeks of resistance-band training on measures of body composition (i.e., whole-body lean tissue mass, total body water), arm and leg muscle thickness (growth), muscle performance (i.e., power, strength, endurance) and functional ability (i.e., walking speed, balance).

A secondary purpose of this research is to examine the effects of bolus ingestion of creatine (5 grams) compared to intermittent ingestion of creatine (2 x 2.5 grams) during 16 weeks of resistance-band training on measures of body composition (i.e., whole-body lean tissue mass, total body water), arm and leg muscle thickness (growth), muscle performance (i.e., power, strength, endurance) and functional ability (i.e., walking speed, balance).

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Key information

Conditions

Aging

Age range

50 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Regina

Regina, Saskatchewan, S4S4H4, Canada

Location status: Recruiting

Location contact

Darren G Candow, PhD

CONTACT

[email protected]

3062090280

Darren G Candow, PhD

CONTACT

About this study

Resistance-band training is safe, conveient, easy-to-use, eliminates potential barriers to exercise participation (i.e., lack of transportation to and from commercial training facilities) and results in high exercise compliance and adherence. Further, resistance-band training results in similar improvements in muscle performance and functional ability compared to traditional resistance-type training using free-weights and machines.

Creatine is a naturally occurring nitrogen-containing compound produced in the body in the liver and brain and can also be found in food products such as red meat and seafood or through commercially available manufactured creatine products.

Evidence-based research shows that creatine supplementation, when ingested during a resistance exercise training program, improves measures of lean mass and muscle growth, muscle performance and functional ability. However, the optimal creatine supplementation protocol to achieve these benefits is unknown.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • if you are 50 years of age and older
  • if you have not been performing more than 1 resistance training session per week for the past 6 weeks or more.

Exclusion criteria

  • if you have taken creatine supplements within 30 days prior to the start of the study
  • if you have pre-existing allergies to the placebo (corn-starch maltodextrin).

Treatment and study plan

Creatine Bolus 5

Dietary Supplement

(Serving 1: 5 grams of creatine + 3 grams of placebo in the morning; Serving 2: 8 grams of placebo at least 6 hours after Serving 1).

Creatine Bolus 3

Dietary Supplement

(Serving 1: 3 grams of creatine + 5 grams of placebo in the morning; Serving 2: 8 grams of placebo at least 6 hours after Serving 1).

Creatine Intermittent 5

Dietary Supplement

(Serving 1: 2.5 grams of creatine + 5.5 grams of placebo in the morning, Serving 2: 2.5 grams of creatine + 5.5 grams of placebo at least 6 hours after Serving 1).

Placebo

Dietary Supplement

(Serving: 8 grams of placebo in the morning; Servings 2: 8 grams of placebo at least 6 hours after Serving 1).

Primary outcomes

  1. Whole-body lean mass (kg)

    Time frame: baseline, week 16

    Bioelectrical impedance analysis

  2. Muscle Hypertrophy (cm)

    Time frame: baseline, week 16

    B-mode ultrasound

  3. Strength (kg)

    Time frame: baseline, week 16

    1-repetition maximum leg press and chest press

  4. Endurance (number of repetitions to fatigue)

    Time frame: baseline, week 16

    Leg press and chest press

  5. Power (feet)

    Time frame: baseline, week 16

    medicine ball throw

  6. Balance (Centre of Pressure)

    Time frame: baseline, week 16

    Force Plate

  7. Gait Speed (meters)

    Time frame: baseline, week 16

    Walking distance

Study contacts

Contact information is provided by the study sponsor or research team.

Darren Candow

CONTACT

[email protected]

306-585-4906

Sponsors and collaborators

Lead sponsor

University of Regina

Other

Collaborators

  • Iovate Health Sciences International Inc

Registry information

Official study title

Effects of Resistance-band Training and Creatine Supplementation in Healthy Older Adults

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Sep 23, 2024
Registry last updated
Sep 23, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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