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OpenTrials
Completed

NCT Number: NCT04533256

Effects of Renal Replacement Therapy With Hemoadsoption in Patients With Sepsis

Hemoadsorption has been demonstrated to improve clinical and paraclinical results in critically ill patients with sepsis and septic shock. The present study investigates the effects of three consecutive sessions of hemoadsorption, performed in accordance to the local protocol for treating patients with sepsis, on organ failure, severity scores and 30-days mortality. Paraclinical results and severity scores were obtained before and after the three consecutive sessions.

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Key information

Conditions

Sepsis Infections Inflammation Pathologic Processes Pathological Conditions, Signs and Symptoms Systemic Inflammatory Response Syndrome

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Fundeni Clinical Institute

Bucharest, 022328, Romania

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patients with sepsis or septic shock who require hemoadsorption in accordance with local guidelines

Exclusion criteria

  • unsigned informed consent
  • duration of therapy under 12 hours
  • death before the three consecutive sessions

Treatment and study plan

CytoSorb

Procedure

three consecutive sessions of hemoadsorption in patients with sepsis

Primary outcomes

  1. 28-days mortality

    Time frame: 28 days after ICU admission

    28-days mortality

Secondary outcomes

  1. severity score

    Time frame: 3 days

    dynamics of SOFA score (Sequential Organ Failure Assessment) calculated as the mathematical difference in post-therapy SOFA score and pre-therapy SOFA score

Sponsors and collaborators

Lead sponsor

Institutul Clinic Fundeni

Other

Registry information

Important dates

Study start
2016
Primary completion
2021
Study completion
2021
First posted
Aug 31, 2020
Registry last updated
Sep 13, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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