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Active, Not Recruiting

NCT Number: NCT06295757

Effects of Relighting on Smoke Toxicant Deliveries and Subjective Smoking Measures

Characterize effects of relighting on smoke toxicant deliveries and subjective smoking measures. This will be a within-subject comparison in a single experimental group of 30 smokers who report engaging in relighting behaviors. We will assess smoking intensity for relit and non-relit (i.e., smoked continuously without relighting) cigarettes in the natural environment and will conduct in-clinic measurements of smoking topography and subjective responses for relit and non-relit cigarettes. Information on relighting patterns and smoking topography collected from each participant will be used to compare machine-measured smoke yields of key harmful constituents when their usual cigarettes are smoked with and without relighting. Hypothesis: Relit cigarettes will produce higher levels of toxicants than non-relit cigarettes.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

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Key information

Conditions

Tobacco Use Behavior Chemically-Induced Disorders Cigarette Smoking Mental Disorders Nicotine Dependence Smoking Substance-Related Disorders Tobacco Smoking Tobacco Use Disorder

Age range

21 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Irina Stepanov, PhD

Minneapolis, Minnesota, 55455, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Smoking at least 10 cigarettes/day for at least 1 year (confirmed by CO > 8 ppm or NicAlert test of 6)
  • Engaging in relighting for at least half of their CPD
  • No smoking quit attempts in the past month nor intentions to quit in the next month
  • Stable medical or psychiatric conditions with systolic blood pressure < 160, diastolic blood pressure < 100 and heart rate < 105 bpm

Exclusion criteria

  • Participant with current or recent alcohol or drug abuse problems, use of substances of abuse (other than marijuana due to high prevalence of co-use) within the past month
  • Currently trying or planning to quit smoking in the next month
  • Planning to become pregnant, pregnant or breastfeeding. Pregnancy exclusion will be confirmed through a urine test.

Treatment and study plan

Cigarettes

Other

Participants will smoke their own usual brand cigarettes. Cigarette butts will be collected.

Primary outcomes

  1. Average Nicotine Level

    Time frame: 1 month

    Level of nicotine in cigarette butts collected during study.

Secondary outcomes

  1. Average Puff Volume

    Time frame: 1 month

    In-clinic measurement of puff volume using topography device.

Sponsors and collaborators

Lead sponsor

Masonic Cancer Center, University of Minnesota

Other

Collaborators

  • National Cancer Institute (NCI)

Registry information

Important dates

Study start
2024
Primary completion
2026
Study completion
2028
First posted
Mar 6, 2024
Registry last updated
Jul 13, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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