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OpenTrials
Completed

NCT Number: NCT01715337

Effects of Rehabilitation on Muscle Fibre Composition and Capillaries in Chronic Obstructive Pulmonary Disease (COPD) Patients

Pulmonary rehabilitation has been established as an evidence-based and recommended therapy in patients with chronic obstructive pulmonary disease (COPD). The aim of our study is to show a potential change in muscle fibre composition and in the amount of capillaries in quadriceps muscle from pre tob post 3-week rehabilitation. Pulmonary rehabilitation includes standardised exercise training, e.g. cycling and strength training for major muscle groups.

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Key information

Conditions

Chronic Obstructive Pulmonary Disease Chronic Disease Disease Attributes Lung Diseases Lung Diseases, Obstructive Pathologic Processes Pathological Conditions, Signs and Symptoms Pulmonary Disease, Chronic Obstructive Respiratory Tract Diseases

Age range

40 year–75 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Schön Klinik Berchtesgadener Land

Schönau am Königssee, 83471, Germany

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • chronic obstructive pulmonary disease
  • FEV1%pred. < 50%

Exclusion criteria

  • acute exacerbation
  • exacerbation in the last 4 weeks

Treatment and study plan

Pulmonary Rehabilitation

Other

3-week rehabilitation including exercise training, breathing therapy, psychosocial support, medical treatment etc.

Primary outcomes

  1. Change in the amount of capillaries in muscle fibre type I

    Time frame: change from pre (day 1) to post rehabilitation (day 21)

Secondary outcomes

  1. Change in the amount of capillaries in muscle fibre type IIa

    Time frame: Change from pre (day 1) to post rehabilitation (day 21)

  2. Change in the cross-sectional area of muscle fibre type I

    Time frame: Change from pre (day 1) to post rehabilitation (day 21)

  3. Change in the cross-sectional area of muscle fibre type IIa

    Time frame: Change from pre (day 1) to post rehabilitation (day 21)

Sponsors and collaborators

Lead sponsor

Schön Klinik Berchtesgadener Land

Other

Collaborators

  • German Sport University, Cologne

Registry information

Official study title

Effects of Pulmonary Rehabilitation on Muscle Fibre Composition and Capillaries in Patients With Chronic Obstructive Pulmonary Disease (COPD)

Important dates

Study start
2010
Primary completion
2013
Study completion
2014
First posted
Oct 26, 2012
Registry last updated
Apr 15, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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