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Completed

NCT Number: NCT02012400

Effects of Regular Exercise on Adult Asthma

The purpose of this study is to assess the effects of regular exercise on physical fitness, asthma control, and quality of life among adult asthmatics.

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Key information

Conditions

Asthma Behavior Bronchial Diseases Hypersensitivity Hypersensitivity, Immediate Immune System Diseases Lung Diseases Lung Diseases, Obstructive Motor Activity Respiratory Hypersensitivity Respiratory Tract Diseases

Age range

16 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Center for Environmental and Respiratory Health Research, University of Oulu

Oulu, 90014, Finland

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • diagnosis of asthma made by physician, or reimbursement for asthma medication from the National Social Insurance Institution of Finland (code 203), or patient fulfills the diagnostic criteria for asthma as outlined in the Finnish Guidelines for Asthma Management (Käypä hoito -suositus 2006 and 2012)

Exclusion criteria

  • FEV1 < 60 % of predicted in spirometry
  • PEF variability > 30 % at least 2 times during a 1-week monitoring period
  • use of bronchodilating medication at least 4 times daily
  • permanent, daily steroid tablet treatment
  • patients who exercise regularly already at baseline at least 3 times a week at least 30 min at a time
  • serious coronary heart disease
  • severe hypotension
  • severe heart failure
  • severe musculoskeletal disorder
  • dementia
  • physician-diagnosed chronic obstructive lung disease

Treatment and study plan

Exercise

Other

The exercise group is given a 24-week individualized training program, including aerobic exercise, muscular training, relaxation exercises and stretching. Patients are asked to observe their asthma control daily and to mark in their diary asthma symptoms and activity limitations as well as duration, intensity and form of exercising on daily basis. They are also asked to perform PEF-measurements twice a day for one-week period every 4 weeks. The control group receives ordinary instructions.

Primary outcomes

  1. Asthma control

    Time frame: 6-month period

    Asthma control based on symptom score and PEF-values

Secondary outcomes

  1. Physical fitness

    Time frame: Baseline and 6 months

    Physical fitness measured with spiroergometry

Other outcomes

  1. Lung function

    Time frame: Baseline and 6 months

    Lung function measured with spirometry

  2. Quality of Life

    Time frame: Baseline and 6 months

    Quality of life assessed using St. Georges Respiratory Questionnaire

  3. Step test

    Time frame: Baseline and 6 months

    Indirect maximal oxygen consumption test using with 6 min step-walk-test

  4. Muscle strength and flexibility

    Time frame: Baseline and 6 months

    Muscle strength and flexibility tests

Sponsors and collaborators

Lead sponsor

University of Oulu

Other

Collaborators

  • Foundation of the Finnish Anti-Tuberculosis Association
  • GlaxoSmithKline
  • Ida Montini Foundation
  • Jalmari and Rauha Ahokas Foundation
  • Oulu University Hospital
  • Research Foundation of the Pulmonary Diseases
  • Vaino and Laina Kivi Foundation

Registry information

Official study title

Effects of Regular Exercise on Physical Fitness, Asthma Control and Quality of Life of Adult Asthmatics

Important dates

Study start
2011
Primary completion
2015
Study completion
2015
First posted
Dec 16, 2013
Registry last updated
May 11, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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