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Completed

NCT Number: NCT05492357

Effects of Recurrent Application of Liquid-PRF on Hard and Soft Tissues

Procedure: Tooth is extracted, then A-PRF+ is placed inside the socket. After that the ridge dimensions is asses clinically at the baseline) in addition to clinical assessment of the gingival biotype at the baseline.

Then patients will be divided into 2 groups:

Group 1: 50% of patients will have recurrent Liquid-PRF injections inside the extraction socket every 2 weeks (A-PRF+, followed by recurrent Liquid-PRF) Group 2: 50% of patients without recurrent (just A-PRF+) After 3 months from extraction: both groups will be assessed clinically (gingival biotype) & (Ridge dimensions) in order to assess the role of recurrent application of Liquid-PRF on these parameters.

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Key information

Conditions

Liquid-PRF A-PRF Plus Disease Attributes Pathologic Processes Pathological Conditions, Signs and Symptoms Recurrence

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Cezar Lahham

Bethlehem, 00000, Palestinian Territories

About this study

In this study, we will select 20 patients who need a simple tooth extraction, then determine the gingival biotype, take a blood sample to prepare A-PRF+ (centrifugation of the patient's blood for 8 min at 1300 rpm using red caps tubes), then do the extraction. After that, A-PRF+ is prepared and inserted into the extraction socket, and sutured using horizontal mattress suturing technique.

After the clinical assessment of the ridge dimensions at the baseline

Then patients will be divided into 2 groups:

Group 1: 10 patients will have recurrent Liquid-PRF injections inside the extraction socket every 2 weeks (A-PRF+, followed by recurrent Liquid-PRF) Liquid-PRF preparation: Centrifugation of the patient's blood for 8 min at 2500 rpm using white caps tubes.

Group 2: 10 patients without recurrent application of Liquid-PRF (just A-PRF+) After 3 months from extraction: both groups will be assessed clinically (gingival biotype) & (Ridge dimensions) in order to evaluate the effect of recurrent application of Liquid-PRF on these parameters.

Assessment method:

for Hard tissue evaluation (Bone): we assess the dimensions clinically For soft tissue: we will use a periodontal probe to assess the gingival thickness after giving local anesthesia.

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Selection Criteria

Inclusion criteria

  • Men and women over 18 years of age
  • Indication of a simple extraction
  • Delivery of signed informed consent

Exclusion criteria

  • Need for multiple extractions
  • Presence of severe swelling prior to surgery in the extraction area
  • Regular treatment with non-steroidal anti-inflammatory drugs (NSAIDs) or other anti-inflammatory drugs
  • Presence of hematologic disease
  • Previous radiation, chemotherapy, or immunosuppressive treatments
  • Uncontrolled diabetes mellitus, metabolic bone disease, ongoing treatment with bisphosphonates drugs, or pregnancy

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Men and women over 18 years of age
  • Indication of a simple extraction (Non-molar tooth)
  • Delivery of signed informed consent
  • Need delayed implant placement in the place of extraction

Exclusion criteria

  • Need for multiple extractions
  • Presence of severe swelling prior to surgery in the extraction area
  • Regular treatment with non-steroidal anti-inflammatory drugs (NSAIDs) or other anti-inflammatory drugs
  • Presence of hematologic disease
  • Previous radiation, chemotherapy, or immunosuppressive treatments
  • Uncontrolled diabetes mellitus, metabolic bone disease, ongoing treatment with bisphosphonates drugs, or pregnancy

Treatment and study plan

Liquid platelet-rich fibrin

Other

Liquid platelet-rich fibrin is prepared from the patient's blood and injected into the extraction socket every two weeks (up to 3 months = Just 4 times of application)

Other names: Liquid-PRF

Advanced Platelet-rich fibrin plus

Other

A-PRF+ is placed into the extraction socket immediately after tooth extraction

Primary outcomes

  1. Ridge dimensions

    Time frame: 3 months

    assessment of ridge dimensions 3 months after intervention for both groups. At the baseline it was assessed clinically. After 3 months, the flap was released and the ridge width and height were assessed clinically.

  2. Gingival biotype

    Time frame: 3 months

    assessment of gingival biotype 3 months after intervention according to gingival thickness (using periodontal probe: if <1 mm = Thin, while if >1 =Thick).

Sponsors and collaborators

Lead sponsor

Cezar Edward Lahham

Other

Registry information

Official study title

The Effect of Recurrent Application of Liquid Platelet-rich Fibrin in the Extraction Socket on the Hard and Soft Tissues. A Randomised Controlled Trial

Acronym: Liquid-PRF

Important dates

Study start
2022
Primary completion
2022
Study completion
2022
First posted
Aug 8, 2022
Registry last updated
Nov 9, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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