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NCT Number: NCT06230861

Effects of Quercetin on Cardiometabolic Outcomes

Cardiovascular disease, type 2 diabetes mellitus and associated diseases combined are the leading health burden and cause of mortality worldwide; therefore, the necessity for an intervention is paramount. Dietary interventions to improve cardiometabolic health are highly sought after as they possess less risk than pharmacological drugs. It has been postulated that Quercetin may be beneficial in improving cardiometabolic outcomes. However, to date, no research has explored this using a placebo randomized intervention.

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Key information

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Central Lancashire

Preston, Lancashire, PR4 0PE, United Kingdom

Location status: Recruiting

Location contact

Jonathan Sinclair, DSc, PhD

CONTACT

[email protected]

07875651533

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy
  • Between 18 & 65 years
  • Non-smoker
  • BMI < 30
  • Able to give informed consent

Exclusion criteria

  • Pregnancy
  • Diabetes or any other metabolic/ uncontrolled hypertensive conditions
  • Food allergies to quercetin
  • Habitual consumption of quercetin
  • Not regularly taking medication or antioxidant supplements

Treatment and study plan

Quercetin

Dietary Supplement

Quercetin tablets 500mg 1 x per day

Placebo

Other

Placebo control 1 x blinded placebo tablet per day

Primary outcomes

  1. Systolic blood pressure

    Time frame: Baseline

    Systolic blood pressure - measured using a digital blood pressure monitor

  2. Systolic blood pressure

    Time frame: 20 days

    Systolic blood pressure - measured using a digital blood pressure monitor

Secondary outcomes

  1. Diastolic blood pressure

    Time frame: Baseline

    Diastolic blood pressure - measured using a digital blood pressure monitor

  2. Diastolic blood pressure

    Time frame: 20 days

    Diastolic blood pressure - measured using a digital blood pressure monitor

  3. Percent bodyfat

    Time frame: Baseline

    Participants percentage composition of fat - measured using bio-electrical impedance

  4. Percent bodyfat

    Time frame: 20 days

    Participants percentage composition of fat - measured using bio-electrical impedance

  5. Waist to hip ratio

    Time frame: Baseline

    Ratio of waist to hip circumference - measured using anthropocentric tape

  6. Waist to hip ratio

    Time frame: 20 days

    Ratio of waist to hip circumference - measured using anthropocentric tape

  7. Blood glucose

    Time frame: Baseline

    Capillary blood glucose - mmol/L

  8. Blood glucose

    Time frame: 20 days

    Capillary blood glucose - mmol/L

  9. Blood triglycerides

    Time frame: Baseline

    Capillary blood triglycerides - mmol/L

  10. Blood triglycerides

    Time frame: 20 days

    Capillary blood triglycerides - mmol/L

  11. Triglyceride glucose index

    Time frame: Baseline

    Calculated as the natural logarithm of (blood triglycerides x blood glucose) /2)

  12. Triglyceride glucose index

    Time frame: 20 days

    Calculated as the natural logarithm of (blood triglycerides x blood glucose) /2)

  13. Blood cholesterol (Total, HDL & LDL)

    Time frame: Baseline

    Capillary blood cholesterol - mmol/L

  14. Blood cholesterol (Total, HDL & LDL)

    Time frame: 20 days

    Capillary blood cholesterol - mmol/L

  15. Coop-Wonka chart

    Time frame: Baseline

    Psychological wellbeing - The Coop-Wonka chart is a six item questionnaire with a 1-5 scoring

  16. Coop-Wonka chart

    Time frame: 20 days

    Psychological wellbeing - The Coop-Wonka chart is a six item questionnaire with a 1-5 scoring

  17. Beck Depression Inventory

    Time frame: Baseline

    Psychological wellbeing - the Beck Depression Inventory is a 21 questionnaire with questions that range in scoring from 0-3, thus the maximum score is 63 which is the highest depression score possible.

  18. Beck Depression Inventory

    Time frame: 20 days

    Psychological wellbeing - the Beck Depression Inventory is a 21 questionnaire with questions that range in scoring from 0-3, thus the maximum score is 63 which is the highest depression score possible.

  19. State Trait Anxiety Inventory

    Time frame: Baseline

    Psychological wellbeing - the state trait anxiety inventory is a 40 item questionnaire with each question having a 1-4 score system, thus the maximum score is 80 which indicates the highest level of anxiety.

  20. State Trait Anxiety Inventory

    Time frame: 20 days

    Psychological wellbeing - the state trait anxiety inventory is a 40 item questionnaire with each question having a 1-4 score system, thus the maximum score is 80 which indicates the highest level of anxiety.

  21. Insomnia Severity Index

    Time frame: Baseline

    Sleep quality - The Insomnia Severity Index is a brief instrument designed to assess the severity of both nighttime and daytime components of insomnia. The Insomnia Severity Index is a 7-item self-report questionnaire yielding a total score ranging from 0 to 28.

  22. Insomnia Severity Index

    Time frame: 20 days

    Sleep quality - The Insomnia Severity Index is a brief instrument designed to assess the severity of both nighttime and daytime components of insomnia. The Insomnia Severity Index is a 7-item self-report questionnaire yielding a total score ranging from 0 to 28.

  23. Pittsburgh Sleep Quality Index

    Time frame: Baseline

    Sleep quality - The Pittsburgh Sleep Quality index, is a questionnaire that consists of 19 self-rated questions, grouped into 7 components. Each component is scored separately, weighted equally on a 0 - 3 scale and the scores of the 7 components are then added to give a global score, which has a range of 0 - 21 with higher scores indicating worse sleep quality.

  24. Pittsburgh Sleep Quality Index

    Time frame: 20 days

    Sleep quality - The Pittsburgh Sleep Quality index, is a questionnaire that consists of 19 self-rated questions, grouped into 7 components. Each component is scored separately, weighted equally on a 0 - 3 scale and the scores of the 7 components are then added to give a global score, which has a range of 0 - 21 with higher scores indicating worse sleep quality.

  25. Epworth Sleepiness Scale

    Time frame: Baseline

    Sleep quality - The Epworth Sleepiness Scale is a self-administered questionnaire with 8 questions. Respondents are asked to rate, on a 4-point scale (0-3) with a maximum score of 24.

  26. Epworth Sleepiness Scale

    Time frame: 20 days

    Sleep quality - The Epworth Sleepiness Scale is a self-administered questionnaire with 8 questions. Respondents are asked to rate, on a 4-point scale (0-3) with a maximum score of 24.

Study contacts

Contact information is provided by the study sponsor or research team.

Jonathan Sinclair, PhD, DSc

CONTACT

[email protected]

+447875651533

Sponsors and collaborators

Lead sponsor

University of Central Lancashire

Other

Collaborators

  • DoNotAge.org

Registry information

Official study title

Effects of Quercetin Supplementation on Cardiometabolic Parameters

Important dates

Study start
2024
Primary completion
2026
Study completion
2026
First posted
Jan 30, 2024
Registry last updated
Feb 27, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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