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OpenTrials
Completed

NCT Number: NCT01173328

Effects of Pursed-lip Breathing on Exercise Tolerance and Dynamic Hyperinflation in COPD

Pursed-lip breathing (PLB) has been advocated to reduce respiratory rate and improve oxygen saturation in patients with chronic obstructive pulmonary disease (COPD) at rest. Although PLB is a strategy that potentially reduces expiratory flow limitation, there are only few studies addressing its effects on exercise.

This study aimed to assess the ability of PLB to change the breathing pattern, degree of dynamic hyperinflation (DH) and arterial oxygenation in COPD patients during exercise. Exercise tolerance was evaluated by endurance time and respiratory mechanics was evaluated by forced oscillation technique.

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Key information

Conditions

Chronic Obstructive Pulmonary Disease Chronic Disease Disease Attributes Lung Diseases Lung Diseases, Obstructive Pathologic Processes Pathological Conditions, Signs and Symptoms Pulmonary Disease, Chronic Obstructive Respiratory Tract Diseases

Age range

40 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Clementino Fraga Filho University Hospital

Rio de Janeiro, Brazil

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Clinical diagnosis of chronic obstructive pulmonary disease (COPD)
  • Regular treatment at Clementino Fraga Filho University Hospital (UFRJ)

Exclusion criteria

  • Exacerbation in the preceding 4 weeks
  • SpO2<85% at peak exercise
  • Other diseases that may contribute to dyspnea and exercise intolerance

Treatment and study plan

Pursed-lip breathing

Behavioral

Pursed-lip breathing involves a nasal inspiration followed by expiratory blowing against partially closed lips, avoiding forceful exhalation.

Normal Breathing

Behavioral

Primary outcomes

  1. Endurance time

    Time frame: within the first 01 hour

Secondary outcomes

  1. inspiratory capacity

    Time frame: within the first 01 hour

  2. oxygen saturation

    Time frame: within the first 01 hour

  3. dyspnea

    Time frame: within the first 01 hour

  4. forced oscillation variables

    Time frame: within the first 01 hour

Sponsors and collaborators

Lead sponsor

Universidade Federal do Rio de Janeiro

Other

Registry information

Official study title

Effects of Pursed-lip Breathing on Exercise Tolerance and Dynamic Hyperinflation in Chronic Obstructive Pulmonary Disease

Important dates

Study start
2007
Primary completion
2009
Study completion
2009
First posted
Aug 2, 2010
Registry last updated
Aug 2, 2010

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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