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Completed

NCT Number: NCT02766062

Effects of Propofol and Sevoflurane on Early POCD in Elderly Patients With Metabolic Syndrome

The purpose of this study is to investigate propofol versus sevoflurane anesthesia on the effects of early postoperative cognitive function in elderly patients with metabolic syndrome.

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Key information

Conditions

Postoperative Complications Cognition Disorders Cognitive Dysfunction Glucose Metabolism Disorders Hyperinsulinism Insulin Resistance Mental Disorders Metabolic Diseases Metabolic Syndrome Neurocognitive Disorders Nutritional and Metabolic Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Cognitive Complications

Age range

60 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

About this study

By now, a series risk factors of cardiovascular diseases, which are also related to the development of postoperative cognitive dysfunction (POCD), are becoming more common.The investigators don't know whether propofol based anesthesia has a more severe impact on early postoperative cognitive function than sevoflurane in elderly patients with metabolic syndrome. In this study, the investigators want to investigate propofol versus sevoflurane anesthesia on the effects of early postoperative cognitive function in elderly patients with metabolic syndrome.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • aged ≥60 years;
  • ASAⅡor Ⅲ
  • noncardiac surgery and nonneural surgery

Exclusion criteria

  • Mini Mental State Examination [MMSE] score too low
  • chronic alcoho and drug abuse
  • disturbed renal and liver function
  • history of a cerebrovascular accident
  • permanent ventricular pacing
  • preoperative cognitive deficits
  • lack of cooperation

Treatment and study plan

Metabolic Syndrome

Other

metabolic syndrome

Primary outcomes

  1. Number of participants with Postoperative cognitive dysfunction (POCD) as assessed by Mini-Mental State Examination (MMSE) score in propofol group and sevoflurane group

    Time frame: up to 7days postoperatively

Sponsors and collaborators

Lead sponsor

General Hospital of Ningxia Medical University

Other

Registry information

Official study title

Effects of Propofol and Sevoflurane on Early Postoperative Cognitive Dysfunction in Elderly Patients With Metabolic Syndrome

Important dates

Study start
2015
Primary completion
2016
Study completion
2016
First posted
May 9, 2016
Registry last updated
Jun 30, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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