Effects of Pomegranate Seed Oil Supplementation in Patients With Advanced Dementia

Urinary Tract Infections were diagnosed using the revised McGeer criteria for the diagnosis of UTIs in Stone et al. (2012):

Criteria from both 1 and 2

• At least 1 of the following:

Acute dysuria or acute pain, swelling, or tenderness of the testes, epididymis, or prostate OR

Fever or leukocytosis and at least 1 of the following localizing urinary tract sub-criteria:

Acute costovertebral angle pain or tenderness Suprapubic pain Gross hematuria New or marked increase in incontinence New or marked increase in urgency New or marked increase in frequency

In the absence of fever or leukocytosis, then 2 or more of the following:

Suprapubic pain Gross hematuria New or marked increase in incontinence New or marked increase in urgency New or marked increase in frequency

• One of the following:

At least 10^5 cfu/mL of no more than 2 species of microorganisms in a voided urine sample At least 10^2 of any number of organisms in a specimen collected by in-and-out catheter

Recurrent UTIs were classified as more than one UTI diagnosed in a single patient based on the criteria proposed in Stone et al. (2012) as described previously.

As in Stone et al. (2012):

All 3 criteria must be present:

• Interpretation of a chest radiograph as demonstrating pneumonia or the presence of a new infiltrate
• At least 1 of the following respiratory subcriteria

• New or increased cough
• New or increased sputum production
• O2 saturation <94% on room air or a reduction in O2 saturation of >3% from baseline
• New or changed lung examination abnormalities
• Pleuritic chest pain
• Respiratory rate of ≥25 breaths/min
• At least 1 of the following criteria

• Fever
• Leukocytosis
• Acute change in mental status from baseline and either disorganized thinking or altered level of consciousness
• Acute functional decline