Skip to main content
OpenTrials
Completed

NCT Number: NCT06900894

Effects of Platelet-Rich Fibrin and Kinesio Taping on Postoperative Recovery in Oral Surgery

This study investigates the effectiveness of Platelet-Rich Fibrin (PRF) and Kinesio Taping in reducing postoperative pain, edema, and improving recovery following impacted third molar surgery. A prospective, randomized clinical trial was conducted with 44 patients aged 18-35 years. Patients were assigned to three groups: (1) PRF applied locally to the extraction socket, (2) Kinesio Taping applied postoperatively and removed on the third day, and (3) a control group receiving standard postoperative care. Postoperative outcomes were assessed on days 3 and 7, including pain levels, edema, and quality of life. This study aims to evaluate PRF and Kinesio Taping as non-pharmacological adjuncts in oral and maxillofacial surgery.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Impacted Third Molar Tooth Neurologic Manifestations Pain Pain, Postoperative Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Complications Postoperative Edema Postoperative Pain Signs and Symptoms

Age range

18 year–35 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Hatay Mustafa Kemal University, Faculty of Dentistry

Hatay, 31001, Turkey (Türkiye)

About this study

This study investigates the effectiveness of Platelet-Rich Fibrin (PRF) and Kinesio Taping in postoperative management following impacted mandibular third molar surgery. Postoperative complications, such as pain and edema, are commonly observed and may impact patient comfort and recovery. This study aims to evaluate the feasibility of two non-pharmacological approaches-PRF and Kinesio Taping (Elastic Bandaging)-in postoperative care.

A total of 44 patients aged 18-35 years participated in this prospective, randomized clinical trial. Patients were assigned to one of three groups:

PRF Group: Platelet-rich fibrin (PRF) was applied locally into the extraction socket.

Kinesio Taping Group: An elastic bandage was applied postoperatively to the surgical area and removed on the third day.

Control Group: Standard postoperative care was provided with no additional intervention.

Postoperative evaluations were conducted on the 3rd and 7th days. The measured parameters included:

Edema: Measured using anthropometric techniques.

Pain: Assessed with the Numerical Rating Scale (NRS).

Quality of Life: Evaluated using the Oral Health Impact Profile-14 (OHIP-14).

This study aims to assess the feasibility of PRF and Kinesio Taping in postoperative management.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Ages 18-35 years
  • Systemically healthy individuals
  • Non-smokers
  • No psychological disorders
  • Preoperative pain level between 0-3 on the Numerical Rating Scale (NRS)
  • No preoperative edema in the surgical area
  • Impacted mandibular third molars classified as Class 1 or 2, Level B, and mesioangular according to the Pell-Gregory classification
  • Signed an informed consent form

Exclusion criteria

  • Under 18 or over 35 years old
  • Presence of chronic or systemic diseases
  • Pregnant or breastfeeding patients
  • Surgical duration exceeding 45 minutes
  • Smokers
  • Patients requiring prophylactic antibiotics due to systemic health conditions
  • Patients who did not meet the study criteria or did not sign the informed consent form

Treatment and study plan

Platelet-rich fibrin (PRF)

Biological

PRF was prepared using a centrifugation protocol and applied to the extraction socket.

Kinesio taping

Device

Kinesio Tape was applied postoperatively to the masseter and submandibular region.

Standard Postoperative Care

Other

Patients in the control group received standard postoperative care.

Primary outcomes

  1. Postoperative Pain Assessment (NRS)

    Time frame: Preoperative day 1, postoperative days 3 and 7

    The pain intensity of the patients will be assessed using the Numerical Rating Scale (NRS) on preoperative day 1 and postoperative days 3 and 7.

    On this scale: 0 indicates no pain, 10 indicates the worst imaginable pain. Before the procedure, patients were informed about the scale and instructed to rate their pain intensity accordingly.

  2. Postoperative Facial Swelling Assessment

    Time frame: Preoperative day 1, postoperative days 3 and 7

    Swelling will be evaluated using anthropometric measurement techniques on preoperative (surgery day), postoperative days 1, 3, and 7.

    Measurement methods:

    Lateral canthus-gonion distance (distance from the outer corner of the eye to the mandibular angle) Commissure-tragus distance (distance from the oral commissure to the midpoint of the tragus) All measurements were performed using a flexible ruler, and the results were recorded in millimeters.

  3. Oral Health Impact Profile-14 (OHIP-14) Score

    Time frame: Postoperative days 3 and 7

    The quality of life of the patients will be assessed using the OHIP-14 questionnaire on postoperative days 3 and 7.

    OHIP-14 consists of 14 standardized items, each rated on a scale from 0 to 4. Total scores range from 0 to 56, with higher scores indicating worse quality of life.

    This scale was used to evaluate the impact of postoperative complications on patients' quality of life.

Sponsors and collaborators

Lead sponsor

Mustafa Kemal University

Other

Registry information

Official study title

Effectiveness of Platelet-Rich Fibrin and Elastic Bandaging on Postoperative Pain, Edema, and Recovery Following Impacted Molar Surgery: A Randomized Clinical Trial

Acronym: PRFKTOralSur

Important dates

Study start
2023
Primary completion
2024
Study completion
2024
First posted
Mar 28, 2025
Registry last updated
Apr 2, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.