Skip to main content
OpenTrials
Completed

NCT Number: NCT07604584

Effects of Platelet-Rich Fibrin After Mandibular Third Molar Surgery in Smokers and Nonsmokers

Mandibular third molar surgery is commonly associated with postoperative pain, swelling, and trismus. Platelet-rich fibrin (PRF) has been proposed as a biological adjunct to improve postoperative healing; however, its effectiveness in smokers remains unclear. This prospective randomized split-mouth clinical study aimed to evaluate the effects of PRF on postoperative pain, swelling, trismus, and analgesic consumption after impacted mandibular third molar surgery in smokers and nonsmokers. Thirty patients with bilaterally impacted mandibular third molars were included. PRF was placed in one extraction socket, while the contralateral socket served as the control site. Postoperative clinical outcomes were assessed during the first postoperative week and compared between smoking and nonsmoking patients.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Impacted Mandibular Third Molar Behavior Facial Swelling Nervous System Diseases Neurologic Manifestations Neuromuscular Manifestations Pain Pain, Postoperative Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Complications Postoperative Pain Signs and Symptoms Smoking Spasm Trismus

Age range

18 year–35 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Ankara University Faculty of Dentistry

Ankara, 06560, Turkey (Türkiye)

About this study

This prospective randomized split-mouth clinical trial was conducted between 2017 and 2019 at the Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Ankara University. The study aimed to evaluate the effects of platelet-rich fibrin (PRF) on postoperative pain, swelling, trismus, and analgesic consumption after impacted mandibular third molar surgery in smoking and nonsmoking patients.

A total of 30 systemically healthy patients aged 18-35 years with bilaterally impacted mandibular third molars were included. Patients were divided into smoking and nonsmoking groups. In each patient, PRF was randomly applied to one extraction socket, while the contralateral socket served as the control site without PRF application. All surgical procedures were performed by the same oral and maxillofacial surgeon using a standardized surgical protocol. Outcome assessments were performed by a different clinician blinded to the intervention side.

Postoperative pain was evaluated using a visual analog scale (VAS). Facial swelling was assessed using linear facial measurements between anatomical landmarks, and trismus was evaluated by measuring maximum interincisal distance. Clinical evaluations were performed preoperatively and on postoperative days 1, 2, 3, and 7.

The primary outcome of the study was postoperative pain intensity. Secondary outcomes included postoperative swelling, trismus, and analgesic consumption. The study also aimed to compare the clinical effectiveness of PRF between smokers and nonsmokers.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Systemically healthy patients aged between 18 and 35 years
  • Bilaterally impacted mandibular third molars
  • Mandibular third molars classified as Pell and Gregory Class I, Position C
  • Mandibular third molars classified as Parant Class II difficulty
  • Smoking and nonsmoking patients
  • Patients willing to participate and provide written informed consent

Exclusion criteria

  • Presence of acute infection or pericoronitis
  • Pregnancy or lactation
  • Alcohol or substance abuse
  • Use of oral contraceptives
  • Menstrual period during surgery
  • Antibiotic use within the previous month
  • Smoking more than 10 cigarettes per day
  • Agitation or inability to cooperate
  • Incomplete follow-up data
  • Systemic disease contraindicating oral surgery

Treatment and study plan

platelet-rich fibrin

Biological

Autologous platelet-rich fibrin prepared from venous blood by centrifugation and placed into the extraction socket after mandibular third molar extraction.

Primary outcomes

  1. Postoperative Pain Intensity

    Time frame: Postoperative days 1, 2, 3, and 7

    Postoperative pain intensity assessed using a 100-mm visual analog scale (VAS) after impacted mandibular third molar surgery.

Secondary outcomes

  1. Postoperative Facial Swelling

    Time frame: Preoperative period and postoperative days 1, 2, 3, and 7

    Postoperative facial swelling assessed using linear facial measurements between anatomical landmarks.

  2. Postoperative Trismus

    Time frame: Preoperative period and postoperative days 1, 2, 3, and 7

    Trismus assessed by measuring maximum interincisal mouth opening distance.

  3. Postoperative Analgesic Consumption

    Time frame: Postoperative days 1, 2, 3, and 7

    Number of analgesic tablets used during the postoperative follow-up period.

Sponsors and collaborators

Lead sponsor

Ankara University

Other

Registry information

Official study title

Effects of Platelet-Rich Fibrin on Postoperative Pain, Trismus and Swelling After Impacted Mandibular Third Molar Surgery in Smokers and Nonsmokers: A Prospective Clinical Study

Important dates

Study start
2017
Primary completion
2018
Study completion
2018
First posted
May 22, 2026
Registry last updated
May 22, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.