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OpenTrials
Completed

NCT Number: NCT01357044

Effects of Plant Extracts on Semen Quality

this is a prospective randomized placebo-controlled double-blinded trial investigating the effect of plant extracts from Alpinia galanga and Punica granatum on human semen quality. The investigators hypothesize that these plant extracts will improve semen quality.

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Key information

Conditions

Poor Semen Quality

Age range

18 year and older

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Laboratory of Reproductive Biology

Horsens, 8700, Denmark

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Reduced semen quality

Exclusion criteria

  • Total count of motile sperm less than 1 million sperm/ejaculate or more than 200 million sperm/ejaculate

Treatment and study plan

Extracts of Punica granatum and Alpinia galanga

Dietary Supplement

Tablets, two in the morning and two in the evening

Placebo

Dietary Supplement

Tablets, two in the morning and two in the evening

Primary outcomes

  1. Count of motile sperm per ejaculate

    Time frame: Each participant is given plant extract for three months with flanking semen analyses.

Secondary outcomes

  1. Morphology: percentage of morphologically abnormal sperm in the ejaculate

    Time frame: Each participant is given plant extract for three months with flanking semen analyses.

    If we find an increase in the primary outcome measure in data from participants receiving plant extracts and not in those receiving placebo tablets, we wish to further investigate whether sperm morphology also improves when consuming the plant extracts, e.g. whether the percentage of abnormal sperm in an ejaculate decreases in the group of participants receiving the active plant extracts

Sponsors and collaborators

Lead sponsor

Horsens Hospital

Other

Collaborators

  • Videns- og Forskningscenter for Alternativ Behandling

Registry information

Official study title

An Extract of Pomegranate Fruit and Galangal Rhizome Increases the Numbers of Motile Sperm: A Prospective, Randomised, Controlled, Double-Blinded Trial

Important dates

Study start
2011
Primary completion
2012
Study completion
2013
First posted
May 20, 2011
Registry last updated
Oct 9, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.