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Completed

NCT Number: NCT05172661

Effects of Physical-Cognitive Training With Different Task Models in Parkinson's Disease With Mild Cognitive Impairment

The present study will characterize exercise model effects (integrated model vs. consecutive model) of physical-cognitive exercise on dual-task walking control in Parkinson's disease with mild cognitive impairment.

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Key information

Conditions

Mild Cognitive Impairment Basal Ganglia Diseases Brain Diseases Central Nervous System Diseases Cognition Disorders Cognitive Dysfunction Mental Disorders Movement Disorders Nervous System Diseases Neurocognitive Disorders Neurodegenerative Diseases Parkinson Disease Parkinsonian Disorders Synucleinopathies

Age range

40 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

National Taiwan University

Taipei, Taiwan

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • a diagnosis of idiopathic Parkinson's disease
  • have decreased cognitive functions but do not interfere with functional independence
  • Montreal Cognitive Assessment (MoCA): 21-25
  • able to walk independently without walking devices for at least 10 meters and with the ability to turn 180°

Exclusion criteria

  • a diagnosis of dementia
  • other diseases that may influence cognitive functions or walking performance
  • a history of brain surgery
  • modification of the medication during the exercise intervention

Treatment and study plan

Integrated physical-cognitive training

Behavioral

Perform a postural task and a cognitive task at the same time (dual-task model) 70 minutes/session*2 sessions/week*6 weeks

Consecutive physical-cognitive training

Behavioral

Perform a postural task and a cognitive task separately for identical durations 70 minutes/session*2 sessions/week*6 weeks

Primary outcomes

  1. Change from baseline dual-task walking performance at 8 weeks

    Time frame: 8 weeks

  2. Fall frequency

    Time frame: 20 weeks

  3. Change from baseline Montreal Cognitive Assessment (MoCA) score at 8 weeks

    Time frame: 8 weeks

    MoCA: 0-30 points, higher scores mean a better outcome

Sponsors and collaborators

Lead sponsor

National Taiwan University Hospital

Other

Registry information

Official study title

Effects of Physical-Cognitive Training With Different Task Models on Dual-Task Walking in Parkinson's Disease With Mild Cognitive Impairment

Important dates

Study start
2021
Primary completion
2022
Study completion
2022
First posted
Dec 29, 2021
Registry last updated
Feb 2, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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