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Completed

NCT Number: NCT01741584

Effects of Physical Activity on the Brain in Parkinson's Disease (PD)

The aim of the study is to investigate whether exercise improves cognitive and motor functions in Parkinson's disease. To test this hypothesis, the researchers study general brain functions in subjects with PD during a 6-months exercise program.

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Key information

Conditions

Parkinson's Disease Basal Ganglia Diseases Brain Diseases Central Nervous System Diseases Movement Disorders Nervous System Diseases Neurodegenerative Diseases Parkinson Disease Parkinsonian Disorders Synucleinopathies

Age range

35 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Department of Neurology, Charité Universitätsmedizin Berlin

Berlin, State of Berlin, 10117, Germany

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • UPDRS <15
  • L-DOPA responsive
  • <5 yrs since diagnosis

Exclusion criteria

  • severe other diseases
  • MMSE < 26
  • treatment with psychiatric medication

Treatment and study plan

stationary bike exercise

Behavioral

Aerobic

Behavioral

Primary outcomes

  1. UPDRS motor score

    Time frame: Prior to intervention and after 6 months of intervention

Secondary outcomes

  1. Functional/Structural brain changes

    Time frame: Prior to intervention and after 6 months of intervention

  2. Plasma biomarkers

    Time frame: Prior to intervention and after 6 months of intervention

  3. Cognitive Function based on neuropsychological test-performance

    Time frame: Prior to intervention and after 6 months of intervention

Sponsors and collaborators

Lead sponsor

Charite University, Berlin, Germany

Other

Registry information

Important dates

Study start
2010
Primary completion
2014
First posted
Dec 5, 2012
Registry last updated
Mar 16, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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