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Completed

NCT Number: NCT01219231

Effects of Physical Activity on the Brain in Impaired Glucose Tolerance (IGT)

The researchers will investigate whether exercise could provide positive effects on general brain functions in elderly people with impaired glucose tolerance.

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Key information

Conditions

Impaired Glucose Tolerance Behavior Cognition Disorders Cognitive Dysfunction Glucose Intolerance Glucose Metabolism Disorders Hyperglycemia Mental Disorders Metabolic Diseases Motor Activity Neurocognitive Disorders Nutritional and Metabolic Diseases

Age range

50 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Department of Neurology, Charité Universitätsmedizin

Berlin, State of Berlin, Germany

About this study

The age-related degradation of cognitive functions even to the point of neurodegenerative disorders such as Alzheimer's disease are a growing public-health concern with devastating effects.

Referring to animal data, empirical studies, and pilot human trials, exercise should improve cognitive functions such as learning and memory. To test this hypothesis, the researchers study general brain functions in elderly subjects (50-80 years old) with impaired glucose tolerance during a short term exercise program.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • subjects with impaired glucose tolerance
  • 50-65 years old
  • moderate to heavy weight (BMI 25-35)
  • must be able to do exercise intervention

Exclusion criteria

  • diabetes
  • younger than 50 years
  • BMI < 25
  • psychiatric medication
  • severe disease
  • MMSE < 26
  • severe cardiovascular disorders

Treatment and study plan

Exercise

Behavioral

6 months of aerobic exercise

Primary outcomes

  1. Auditory Verbal Learning Task

    Time frame: Prior to intervention and after 6 months of intervention

Secondary outcomes

  1. Functional/Structural brain changes

    Time frame: Prior to intervention and after 6 months of intervention

  2. Plasma biomarkers

    Time frame: Prior to intervention and after 6 months of intervention

Sponsors and collaborators

Lead sponsor

Charite University, Berlin, Germany

Other

Collaborators

  • German Federal Ministry of Education and Research

Registry information

Official study title

Exercise in Elderly Individuals With Impaired Glucose Tolerance: Beneficial for Vasculature and Neurons?

Important dates

Study start
2010
Primary completion
2015
Study completion
2015
First posted
Oct 13, 2010
Registry last updated
Mar 16, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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