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Completed

NCT Number: NCT01770938

Effects of Phototherapy by Low-level Light-emitting Diode Therapy (LEDT) on Clinical, Biochemical, Biomechanical, Histologic and Genetic Responses of Muscle Performance of Young Males Submitted to Physical Strength Training

Muscle performance is largely influenced by modulations in gene expressions of muscle tissue. In this context, light-emitting diode therapy (LEDT) has been used to improve muscle performance in experimental models and human researches. Thereby, the investigators examined modulations in gene expression of muscle tissue as well as biochemical, biomechanic and histologic adaptations influenced by exercise associated to LEDT.

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Key information

Conditions

Healthy

Age range

18 year–28 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Federal University of São Carlos

São Carlos, São Paulo, 13565-905, Brazil

About this study

This study assessed muscle performance in isokinetic dynamometry and led press device, gene expression by RT-PCR, lactate, creatine kinase and morphology of muscle tissue by immunohistochemical analysis

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • healthy males aged between 18 and 28 years with a body mass index (BMI) equal to or less than 26 kg/m2,
  • moderated pattern of physical activity

Exclusion criteria

  • previous injury to the femoral quadriceps or hamstring muscles (within 6 months prior to study),
  • osseous or articular disorder in the lower limbs,
  • cardiovascular system disorders,
  • systemic disease, and
  • taking prescription medicines or using dietary supplements such as muscle mass builders.

Treatment and study plan

Effective light-emitting diode therapy

Device

Other names: LED, LED therapy, Light-emitting diode therapy

Placebo light-emitting diode therapy

Device

Other names: LED, LED therapy, Light-emitting diode therapy

Primary outcomes

  1. Modulations on muscle gene expression by RT-PCR

    Time frame: 12 weeks

Secondary outcomes

  1. Muscle performance in leg press device

    Time frame: 12 weeks

  2. Muscle performance in leg extension device

    Time frame: 12 weeks

  3. Muscle performance in isokinetic dynamometer

    Time frame: 12 weeks

  4. Gene expression

    Time frame: 12 weeks

    Gene expression of muscle tissue by RT-PCR

Other outcomes

  1. Immunohistochemical analysis

    Time frame: 12 weeks

    Immunohistochemical analysis to quantify morphology and cells of muscle tissue as satellite cells.

Sponsors and collaborators

Lead sponsor

Universidade Federal de Sao Carlos

Other

Collaborators

  • Centro de Pequisas de Ótica e Fotônica
  • Fundação de Amparo à Pesquisa do Estado de São Paulo

Registry information

Important dates

Study start
2012
Primary completion
2012
Study completion
2014
First posted
Jan 18, 2013
Registry last updated
Sep 23, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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