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NCT Number: NCT06936020

Effects of Peripheral Somatosensory Stimulation Via Mechanical Pressure on Lower Limb Muscle Strength in Healthy Subjects.

The proprioceptive system and strength are closely related within the sensorimotor system: proprioception enables effective and coordinated muscle activation (including intramuscular and intermuscular coordination or synergistic abilities), which is essential for maintaining the functional stability of joints and preventing injuries-in short, for controlling motor patterns. This principle provides a window through which changes in strength can be observed via peripheral proprioceptive stimulation that activates the muscular system with the goal of increasing recruitment. This justifies the implementation of proprioceptive input in approaches aimed at motor learning.

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Key information

Conditions

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Pedro Victor López Plaza

Barcelona, Spain

About this study

Objective: To determine whether the application of a peripheral proprioceptive stimulus to the neuromuscular motor points of the quadriceps increases strength and neuromuscular activation during the squat movement in the lower limbs of healthy, untrained subjects.

Methods: The design of this study is a randomized crossover clinical trial. All participants (n=36) will randomly receive both the Active and Sham proprioceptive stimulation.The proprioceptive stimulus will consist of intermittent mechanical pressure on the skin, localized at the neuromuscular motor points of the rectus femoris, vastus lateralis, and vastus medialis of the quadriceps. The tissue subjected to precise pressure in these highly innervated neuromuscular zones promotes the stimulation of kinesthetic cortical sensitivity. The outcome variable will be the assessment of Maximum Strength (MS) generated by the participant during the squat movement, from a 90º knee flexion position to full extension. At the moment of peak force, the mean velocity (MV) of the concentric phase of the movement and the maximum load the participant can move will be evaluated. The intervention, assessment, and recruitment will take place at the Faculty of Health Sciences, Blanquerna - Ramon Llull University

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • State of health with no history of neuromuscular injuries
  • Without surgical interventions, or lower limb trauma in the last six months
  • No associated cardiovascular disease
  • No associated severe COPD.
  • AllParticipants are considered untrained if they do not engage in any specific vigorous lower-limb strength training or regularly perform physical exercise or sports activities.

Treatment and study plan

deep peripheral sensory stimulation

Other

The proprioceptive stimulus will consist of intermittent mechanical pressure on the skin, localized at the neuromuscular motor points of the rectus femoris, vastus lateralis, and vastus medialis of the quadriceps. The tissue subjected to this precise pressure in areas of high neuromuscular innervation facilitates the stimulation of kinesthetic cortical sensitivity. The experimental group (EG) will be randomly and crosswise subdivided into two groups, so that both receive the intervention in two different modalities at two different times.

Primary outcomes

  1. Maximum Strength (MS)

    Time frame: estimated time of movement and data collection of 20 minutes

    The outcome variable will consist of the assessment of Maximum Strength (MS) generated by the participant during the squat movement, from a 90º knee flexion position to full extension measured in two units, kilograms and newtons.

Other outcomes

  1. electric neuromuscular activation

    Time frame: estimated time of movement and data collection of 20 minutes

    In addition to strength assessment, portable sensors will be placed to digitize kinematics (knee and foot joint angles) and muscle electrical activity (surface electromyography), related to the variable of neuromuscular activation during the squat movement.

Study contacts

Contact information is provided by the study sponsor or research team.

Pedro V López Plaza

CONTACT

[email protected]

932 53 32 56

Sponsors and collaborators

Lead sponsor

Facultat de ciencies de la Salut Universitat Ramon Llull

Other

Registry information

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Apr 20, 2025
Registry last updated
Apr 30, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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