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OpenTrials
Completed

NCT Number: NCT07215338

Effects of Palmar Cooling on the Human Immune System

This is a research study on human exercise that will investigate the immune system response post-exercise and how it relates to Delayed Onset Muscle Soreness (DOMS), and possible causes for DOMS.

Blood draws (10mL) will be obtained at 5 timepoints: Baseline before intervention, day of exercise immediately following exercise, and post-exercise days 1, 2 and 4.

Point of care lactate levels obtained before and after exercise.

Subjective pain scores recorded daily starting immediately after after exercise.

Completed

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Key information

Conditions

Human Immune Response

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Stanford University

Stanford, California, 94305, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Ability to perform two arm bicep curl of at least 35 lb as 1 repetition maximum

Exclusion criteria

  • Autoimmune disease
  • Steroid use
  • On current immune-modifying treatment

Treatment and study plan

Muscle Temperature Control

Other

The intervention will be placing the palms of the hands on a water perfused pad.

Primary outcomes

  1. Mean change from baseline in phosphorylation markers in the Janus kinase/signal transducer and activator of transcription (JAK/STAT) and Toll-like Receptor (TLR)-pathway in immune cell populations

    Time frame: From enrollment to 5 days after the end of treatment

    Collected at baseline from whole blood prior to exercise, day of exercise, post-exercise day 1, post-exercise day 2, post-exercise day 4

Secondary outcomes

  1. Change from pre-exercise baseline in point of care lactate levels

    Time frame: 1 day

    Two point of care lactate draws before and after exercise obtained in mmol/L

  2. Change in Pain Scores from baseline

    Time frame: From day of intervention daily for 5 days.

    Daily subjective pain scores recorded according to the Borg Perceived Pain Scale from 0 (no pain) to 11 (maximum pain)

Sponsors and collaborators

Lead sponsor

Stanford University

Other

Collaborators

  • Wu Tsai Human Performance Alliance

Registry information

Official study title

Understanding and Mitigating Delayed Onset Muscle Soreness (DOMS)

Important dates

Study start
2024
Primary completion
2024
Study completion
2024
First posted
Oct 10, 2025
Registry last updated
Nov 4, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.