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NCT Number: NCT06902714

Effects of Oral Tranexamic Acid on Short Term Postoperative Outcomes Following Total Shoulder Arthroplasty

The purpose of this clinical trial is to evaluate the short-term clinical outcomes of patients undergoing total shoulder arthroplasty who receive an extended postoperative course of oral tranexamic acid

Recruiting

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Key information

Conditions

Shoulder Arthroplasty

Age range

18 year–79 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 3

Primary location

University of Alabama at Birmingham

Birmingham, Alabama, 35205, United States

Location status: Recruiting

Location contact

Walter Smith

CONTACT

[email protected]

205-930-8554

Walter Smith, MD

PRINCIPAL_INVESTIGATOR

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Skeletally mature patients (ages 18-79) undergoing primary total shoulder arthroplasty

Exclusion criteria

  • Patients with Cancer, venous thromboembolism, stroke, heart disease, pregnant or nursing, allergic to TXA, current tobacco use, anticoagulants other than aspirin.

Treatment and study plan

oral tranexamic acid

Drug

one group of subjects will receive oral tranexamic acid and the other will receive oral placebo

Placebo

Drug

one group of randomized subjects will receive placebo and the other will receive oral tranexamic acid

Primary outcomes

  1. VAS

    Time frame: 2 weeks

    visual analog scale

Study contacts

Contact information is provided by the study sponsor or research team.

Walter Smith

CONTACT

[email protected]

205-930-8554

Sponsors and collaborators

Lead sponsor

University of Alabama at Birmingham

Other

Registry information

Official study title

Evaluating the Effects of Oral Tranexamic Acid on Short Term Postoperative Outcomes Following Total Shoulder Arthroplasty: A Randomized Control Trial

Important dates

Study start
2026
Primary completion
2028
Study completion
2030
First posted
Mar 30, 2025
Registry last updated
Apr 28, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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