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OpenTrials
Completed

NCT Number: NCT00404781

Effects of Optimized Antiplatelet Treatment After Percutaneous Coronary Intervention

Effects of dual antiplatelet therapy with aspirin and clopidogrel after percutaneous coronary intervention has been proven. However, patients with low response to those agents are reported be associated with adverse clinical outcomes. We suppose that optimized antiplatelet therapy for individual patients based on platelet function assay may improve long-term outcomes especially in patients with high risk of thrombosis. In this prospective randomized study, patients in control group all receive standard dual antiplatelet therapy, and patients in optimized group receive different antiplatelet therapy according to risk stratification.

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Key information

Conditions

Ischemic Heart Disease Acute Coronary Syndrome Acute Coronary Syndromes Cardiovascular Diseases Heart Diseases Myocardial Ischemia Vascular Diseases

Age range

35 year–75 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Northern Hospital

Shenyang, Liaoning, 110016, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • non-ST-segment elevated acute coronary syndromes
  • patients undergoing selective or emergent PCI

Exclusion criteria

  • administration of clopidogrel or ticlopidine within 2 weeks
  • ST-segment elevated myocardial infarction
  • contraindications of antiplatelet therapy
  • history of intracranial bleeding
  • known bleeding disorders
  • severe liver or kidney disease

Treatment and study plan

cilostazol in addition to aspirin and clopidogrel

Drug

Primary outcomes

  1. Major adverse cardiac and cerebral events at 1 year

    Time frame: 1 year

Secondary outcomes

  1. Hemorrhage events at 1 year

    Time frame: 1 year

Sponsors and collaborators

Lead sponsor

Shenyang Northern Hospital

Other

Registry information

Official study title

Pilot Study of Personal Optimized Antiplatelet Treatment After Percutaneous Coronary Intervention in Patients With Acute Coronary Syndromes

Important dates

Study start
2006
Primary completion
2007
Study completion
2007
First posted
Nov 29, 2006
Registry last updated
Oct 14, 2009

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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