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OpenTrials
Completed

NCT Number: NCT00732576

Effects of Omega-3 Fatty Acids and Menaquinone-7 on Thrombotic Tendency

Omega-3 fatty acids are notably present in fish oil and krill oil, and are known to have beneficial effects on the vasculature. Vitamin K2 is known for preventing vascular calcification. In this study we investigate a potential synergy between the effects of either fish or krill oil and menaquinone-7, which is one of K2 vitamins.

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Key information

Conditions

Atherosclerosis Arterial Occlusive Diseases Arteriosclerosis Calcinosis Calcium Metabolism Disorders Cardiovascular Diseases Metabolic Diseases Nutritional and Metabolic Diseases Vascular Diseases

Age range

25 year–50 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

VitaK - Maastricht University

Maastricht, 6200 MD, Netherlands

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy subjects - BMI < 30
  • written informed consent

Exclusion criteria

  • Use of oral anticoagulants
  • Coagulation disorders
  • Use of multivitamin supplements
  • Use of corticosteroids, anticonceptives
  • hypertriglyceridemia, hypercholesterolemia

Treatment and study plan

menaquinone-7

Dietary Supplement

capsule consisting of 10, 20 or 45 µg menaquinone-7 per day during 8 weeks

Other names: MenaQ7

Fish Oil

Dietary Supplement

9 fish oil capsules equivalent to 3 gram per day of n-3 polyunsaturated fatty acids during 12 weeks

Krill oil

Dietary Supplement

9 krill oil capsules, equivalent to 1,5 gram per day of n-3 polyunsaturated fatty acids (PUFA) during 12 weeks

Primary outcomes

  1. Endogenous Thrombin Potential (ETP)

    Time frame: 12 weeks

Secondary outcomes

  1. Osteocalcin carboxylation

    Time frame: 12 weeks

  2. Matrix Gla-protein carboxylation

    Time frame: 12 weeks

Sponsors and collaborators

Lead sponsor

Maastricht University Medical Center

Other

Registry information

Important dates

Study start
2008
Primary completion
2008
Study completion
2008
First posted
Aug 12, 2008
Registry last updated
Feb 24, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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