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OpenTrials
Completed

NCT Number: NCT01898858

Effects of O2 and/or CO2 Inhalation on Rest and Exercise Pulmonary Hemodynamic

The aim of this study is to describe the pulmonary hemodynamic evolution at rest and during a short constant load exercise in 4 conditions :

* normoxia * hypoxia * hypercapnia * association hypoxia and hypercapnia

Completed

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Key information

Conditions

Pulmonary Vascular Sensibility in Hypoxia Hypercapnia Hypoxia Hypoxia and Hypercapnia Pathological Conditions, Signs and Symptoms Signs and Symptoms Signs and Symptoms, Respiratory

Age range

18 year–40 year

Sex eligibility

Male

Study type

Observational

Primary location

Service de Physiologie et d'Explorations Fonctionnelles, Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg

Strasbourg, 67091, France

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • healthy male
  • exercise capacity between 100 and 130 % of theorical values

Exclusion criteria

  • smoker
  • headache
  • impossibility to perform an exercise test
  • no tricuspid regurgitation on the echocardiography

Treatment and study plan

Hypercapnia inhalation (Altitrainer NP 190)

Device

Hypercapnia inhalation using an Altitrainer NP 190

Hypoxia and hypercapnia (Altitrainer NP 190)

Device

Hypoxia and hypercapnia inhalation using an Altitrainer NP 190

Hypoxia inhalation (Altitrainer NP 190)

Device

Hypoxia inhalation using an Altitrainer NP 190

Primary outcomes

  1. Systolic Artery Pulmonary Pressure(sPAP) (echocardiography, Cardiac output (impedancemetry), Cardiorespiratory parameters

    Time frame: at the end of the 30th minutes constant load exercise

    At rest and during exercise for each condition

Secondary outcomes

  1. Dyspnea and muscle leg discomfort using a Borg Scale

    Time frame: at the end of the 30th minutes constant load exercise

    In each conditions at rest and during exercise

Sponsors and collaborators

Lead sponsor

University Hospital, Strasbourg, France

Other

Registry information

Acronym: H2PAP

Important dates

Study start
2013
Primary completion
2014
Study completion
2014
First posted
Jul 12, 2013
Registry last updated
Oct 15, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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