Hopital Edouard Herriot
Lyon, Rhône, 69003, France
Location status: Recruiting
Location contact
satnislas ABRARD, MD
CONTACT
NCT Number: NCT06735872
Chest trauma is common in traumatology. Its management is based on ventilatory therapies, among which non-invasive ventilation (NIV) is commonly used. Some studies have shown the benefit of this therapy in hypoxemic patients, avoiding intubation, reducing length of stay and healthcare costs, and even reducing mortality. However, these studies are old and underpowered. High flow oxygen therapy (HFO), which is frequently used in everyday practice, has only one study in chest trauma.
There is still a lack of data to really understand the effects of these techniques on the injured lung after trauma. Therefore, the investigators want to do a NIV or HFO session and directly assess the effects on participants' lungs by doing a CT at the end of the session.
This is a procedure carried out within five days of the initial trauma and consists of either a 10-minute session of non-invasive ventilation or a 10-minute session of high-flow oxygen therapy, depending on which arm the participant is allocated to.
Two chest CTs will be performed: the first as part of usual care before the non-invasive ventilation session or high flow oxygen therapy session, and the second immediately after the 10-minute session.
The investigator's objective is to demonstrate an improvement in lung recruitment with NIV or HFO using CT imaging.
Interested in participating?
Request Info18 year and older
All sexes
Interventional
Not applicable
Lyon, Rhône, 69003, France
Location status: Recruiting
satnislas ABRARD, MD
CONTACT
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Exclusion criteria
This group will receive a unique 10-minute session of non invasive ventilation with standard parameters directly on the CT table. The treatment will be delivered via a naso-buccal mask.
Prior to treatment, each participant will have a planned standard care chest CT.
During the session, a senior intensivist watching for participant's comfort and safety.
This group will receive a unique 10-minute session of high flow oxygen directly on the CT table. The treatment will be delivered via a nasal cannula.
Prior to treatment, each participant will have a planned standard care chest CT.
During the session, a senior intensivist watching for participant's comfort and safety.
Time frame: At day 0
The primary outcome is evaluated by a quantitative method to compare lung volumes before and after ventilations sessions. The aim is to measure pulmonary recruitment which corresponds to the lung volume reaerated by ventilatory techniques (NIV and HFO), meaning the difference between the non-aerated lung volume between after and before the intervention. Thus, recruitment includes the partial or total re-aeration of lung areas initially not aerated before the intervention.
The senior radiologist determine the non aerated volumes on mm3 thanks to a dedicated software. We will use a semi-automatic segmentation can be carried out quickly and reproducibly.
Contact information is provided by the study sponsor or research team.
Hospices Civils de Lyon
Other
Effects of Non-invasive Ventilation and High-flow Oxygen Therapy on the Lung in Hypoxemic Chest Trauma Patients, a Descriptive Experimental CT Scan Study
Acronym: VentiChest
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
Published trials that share one or more normalized conditions with this study.
NCT06777056
Lung Contusion
Bologna, Italy
View Trial DetailsNCT06586060
Lung Contusion
Asyut, Asyut Governorate, Egypt
View Trial DetailsNCT06386120
Lung Contusion
View Trial Details