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Completed

NCT Number: NCT07004114

Effects of Neurocognitive Training on Chronic Ankle Instability

Aim: This study aimed to investigate the effects of neurocognitive training on pain, proprioception, injury-related fear, functional, and neurocognitive performance in athletes with chronic ankle instability (CAI).

Materials and Methods: A total of 30 athletes with CAI, with a mean age of 11.10±1.06 years and residing in Balıkesir, were included in the study. Participants were randomly assigned into two groups using simple randomization: the intervention group (n=15) and the control group (n=15). Two participants from the control group were excluded from the final analyses due to missing post-intervention assessments. The intervention group received a neurocognitive training program conducted twice a week for four weeks, following an initial familiarization week. The training was progressively administered on flat ground, balance mat, BOSU, and inverted BOSU. Both groups were evaluated before and after the 4-week intervention using the following measures: the Identification of Functional Ankle Instability (IdFAI), the Cumberland Ankle Instability Tool (CAIT), pain intensity, proprioception, fear of re-injury, Y Balance Test (YBT), Side Hop Test, Reactive Balance Test (RBT), and Upper Extremity Choice Reaction Time Test.

Results: The results were analyzed.

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Key information

Age range

10 year–18 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Balikesir University

Balıkesir, Bigadiç, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Aged between 10 and 18 years

At least 2 years of active athletic participation

History of ankle sprain with at least 2 inflammatory symptoms (e.g., pain, swelling)

The most recent sprain occurred at least 3 months prior to the study start date

A score of 11 or above on the FABIT (Simon et al., 2012)

A score of ≤27 on the CAIT (Yin et al., 2022)

Willingness to participate in the study

Exclusion criteria

History of hip/pelvis, knee, or ankle surgery within the past year

History of ankle fracture

Diagnosis of a neurological disorder

Presence of vestibular disorders

Treatment and study plan

Neurocognitive training group

Other

Neurocognitive training is a rehabilitation approach that, unlike traditional treatment methods which primarily focus on improving physical performance, emphasizes cognitive functions and psychometric skills. It is a program developed by integrating motor learning strategies and cognitive challenges into neuromuscular training. These cognitive challenges include tasks requiring quick reactions, motor-motor or cognitive-motor tasks (dual-task), congruent and incongruent tasks, exercises involving mathematical calculations (working memory), and response inhibition tasks.

Primary outcomes

  1. Functional Ankle Instability Assessment Using the Identification of Functional Ankle Instability Questionnaire (IDFAI)

    Time frame: from the beginning of the study until the end of the 4th week

    The IDFAI is a self-reported questionnaire consisting of 9 items designed to identify the presence and severity of functional ankle instability. Scores range from 0 to 37, with higher scores indicating greater instability. A score above 11 suggests the presence of instability. Scores are unitless numeric values representing the severity of symptoms and frequency of ankle sprains.

  2. Functional Ankle Instability Evaluation Using the Cumberland Ankle Instability Tool (CAIT)

    Time frame: from the beginning of the study until the end of the 4th week

    The CAIT is a self-assessment tool with 9 items measuring subjective ankle instability. Scores range from 0 (severe instability) to 30 (no instability). A score of 27 or below indicates functional ankle instability. The score is a unitless numeric value that reflects the level of perceived instability and risk of recurrent sprains.

  3. Pain Severity Assessment-Visual Analog Scale (VAS)

    Time frame: from the beginning of the study until the end of the 4th week

    The Visual Analog Scale (VAS) is a 10 cm line ranging from "No pain" to "Worst imaginable pain." Participants mark their pain intensity on the line, which is measured in centimeters to quantify pain severity. This unitless numeric score reflects pain intensity at rest, during training, and post-training in ankles with instability history.

Other outcomes

  1. Proprioception Assessment with Reposition Test (Ankle Dorsiflexion and Plantarflexion Angles)

    Time frame: from the beginning of the study until the end of the 4th week

    Joint Position Sense test evaluates proprioception by measuring the accuracy of reproducing a passively positioned joint angle. The ankle dorsiflexion is set at 10°, and plantarflexion at 20°. The difference between target and reproduced angles is measured in degrees using a goniometer. Lower angular deviation indicates better proprioceptive accuracy.

  2. The Sport Injury Anxiety Scale (SIAS)

    Time frame: from the beginning of the study until the end of the 4th week

    The Sport Injury Anxiety Scale (SIAS) was developed to assess the level of anxiety athletes experience after injury. The Turkish adaptation, validity, and reliability study of the scale was conducted by Caz et al. (2019) with university students participating in amateur sports. An increase in the average score obtained from the scale indicates a higher level of injury-related anxiety (Caz et al., 2019).

  3. Postural Stability Measurement Using Multireha Portable Balance Device (Sway in Millimeters During Single-Leg Stance)

    Time frame: from the beginning of the study until the end of the 4th week

    Using the Multireha portable balance device, postural stability is assessed by measuring the average sway in millimeters in anterior, posterior, medial, and lateral directions during a single-leg stance on the unstable ankle side. Two trials of 30 seconds are conducted. Lower sway values indicate better postural stability.

  4. Dynamic Balance Evaluation Using the Y Balance Test (YBT)

    Time frame: from the beginning of the study until the end of the 4th week

    YBT measures dynamic balance in three directions: anterior, posteromedial, and posterolateral. The composite score is calculated as (sum of three reach distances) / (3 x limb length) × 100, yielding a percentage. Higher percentages reflect better dynamic balance and postural control.

  5. Functional Performance Assessment with the Lateral Hop Test

    Time frame: from the beginning of the study until the end of the 4th week

    Participants perform 10 lateral hops over a 30 cm distance on the affected limb as fast as possible. The shortest completion time of two trials, measured in seconds, is recorded. Lower times indicate better functional performance and ankle stability.

  6. Reactive Balance Performance Using the Reactive Balance Test (RBT) with LED Light System

    Time frame: from the beginning of the study until the end of the 4th week

    RBT combines YBT setup with a smartphone-connected LED system. Participants respond to randomly illuminated lights by touching them quickly without losing balance. Performance metrics include visual-motor reaction time (milliseconds) and accuracy percentage. Two trials are conducted; the second trial is recorded for analysis. Lower reaction times and higher accuracy indicate better reactive balance.

  7. Upper Extremity Choice Reaction Time Test

    Time frame: from the beginning of the study until the end of the 4th week

    Participants sit with dominant hand ready to press LED lights arranged on a table. Lights illuminate randomly every 0.5-2.5 seconds. Reaction time (milliseconds) and accuracy (number of correct responses) over one minute are recorded. This test evaluates selective attention and cognitive-motor processing speed.

Sponsors and collaborators

Lead sponsor

Balikesir University

Other

Registry information

Official study title

The Effects of Neurocognitive Training on Pain, Proprioception, Injury Anxiety, and Functional and Neurocognitive Performance in Athletes With Chronic Ankle Instability

Important dates

Study start
2023
Primary completion
2024
Study completion
2025
First posted
Jun 4, 2025
Registry last updated
Jun 4, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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