Effects of Neoadjuvant Therapy With Carboplatin, Paclitaxel Combined With Anti-PD-1 Drugs on Cognitive Function in Patients With Resectable Head and Neck Squamous Cell Carcinoma

Inclusion criteria

• 1: The patient was diagnosed with head and neck squamous cell carcinoma (stage I-IVA), without treatment, and planned to undergo only surgical treatment or surgical treatment + chemotherapy and immunotherapy.

2: Can speak Chinese and have certain reading and writing skills

3: Healthy group: Dental inpatients with non-oral cancer, no history of neurological diseases, and no previous history of malignant tumors

Exclusion criteria

• 1: Brain tumor, brain injury, or stroke at baseline or during follow-up

2: A history of stroke or a medical condition that puts you at high risk for future dementia or recurrence

3: Active mental illness or active narcotic drug use, including using alcohol more than 4 times per day or more than 4 times per week

4: Neurocognitive diseases that affect cognitive function, such as Parkinson's disease or Alzheimer's disease

5: History of drug-associated encephalopathy or brain infection

6: Patients who change their treatment plan during treatment

7: Patients who are currently taking or have taken antidepressants