Marmara University Faculty of Medicine, Basibuyuk Campus
Istanbul, 34854, Turkey (Türkiye)
Location status: Recruiting
Location contact
İlayda AKARSU KAYA, Anesthesiology Resident, Principal Investigator
CONTACT
Recruiting
NCT Number: NCT07325773
Effects of Magnesium Sulfate on Oxygenation and Lung Mechanics During One-Lung Ventilation
This prospective observational study aims to evaluate the effects of intravenous magnesium sulfate on intraoperative oxygenation and lung mechanics in patients undergoing thoracic surgery with one-lung ventilation. Magnesium sulfate has been reported to have potential bronchodilatory and anti-inflammatory properties, which may improve gas exchange and respiratory mechanics during lung isolation.
In this study, patients who receive magnesium sulfate as part of standard anesthetic management will be compared with those who do not receive the drug. Oxygenation parameters, dynamic and static lung mechanics, airway pressures, and ventilation-related indices will be recorded throughout the intraoperative period. The findings of this study may help clarify whether magnesium sulfate provides measurable respiratory benefits during one-lung ventilation.
Recruiting
Interested in participating?
Request InfoKey information
Age range
18 year–80 year
Sex eligibility
All sexes
Study type
Observational
Primary location
Who can participate
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Adults aged 18 to 80 years Scheduled for elective thoracic surgery performed with video-assisted thoracoscopic surgery (VATS) requiring one-lung ventilation under general anesthesia.
ASA physical status II-III Ability to provide informed consent Undergoing general anesthesia with double-lumen tube placement
Exclusion criteria
- Patients undergoing pneumonectomy
- Patients with renal, hepatic, or cardiovascular failure
- Patients with a BMI < 15 kg/m² or > 35 kg/m²
- Patients with a preoperative pulmonary function test showing FEV₁ < 1.5 liters
- Patients who are transferred to the intensive care unit intubated in the postoperative period
- Patients with physical or mental conditions that prevent the performance of pulmonary function testing factors
Treatment and study plan
Primary outcomes
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Change in Intraoperative Oxygenation (PaO₂/FiO₂ Ratio)
Time frame: From induction of anesthesia to the end of one-lung ventilation (approximately 2-3 hours)
The PaO₂/FiO₂ ratio will be measured to evaluate intraoperative oxygenation during the surgery. Measurements will be recorded after induction of anesthesia (baseline) and at predefined intraoperative time points. The primary outcome is the change in PaO₂/FiO₂ ratio between baseline and intraoperative measurements in patients receiving magnesium sulfate versus control.
Secondary outcomes
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Changes in Airway Pressures (Peak and Plateau Pressures)
Time frame: From induction of anesthesia to the end of one-lung ventilation (approximately 2-3 hours).
Peak inspiratory pressure (PIP) and plateau pressure (Pplat) will be measured to assess changes in airway pressures during one-lung ventilation in patients receiving magnesium sulfate compared with control.
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Dynamic Lung Compliance and Airway Resistance (Raw)
Time frame: Intraoperative period (approximately 2-3 hours).
Dynamic compliance (Cdyn) will be recorded at predefined intraoperative time points to evaluate changes in pulmonary mechanics associated with magnesium sulfate administration.Airway resistance (Raw) will be measured at predefined intraoperative time points using ventilator-derived data. Raw will be compared between patients receiving magnesium sulfate and those in the control group to assess the effect of magnesium sulfate on airway resistance during one-lung ventilation.
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Postoperative Arterial Oxygen Partial Pressure (PaO₂) on Room Air
Time frame: Within the first postoperative hour while breathing room air.
Arterial oxygen partial pressure (PaO₂) will be measured in the postoperative period while patients are breathing room air. This outcome will be used to assess whether intraoperative magnesium sulfate administration has an effect on early postoperative oxygenation following one-lung ventilation.
Study contacts
Contact information is provided by the study sponsor or research team.
Meliha ORHON ERGÜN
CONTACT
İlayda AKARSU KAYA, Anesthesiology Resident, Principal Investigator
CONTACT
Sponsors and collaborators
Lead sponsor
Marmara University
Other
Registry information
Official study title
Effects of Magnesium Sulfate on Intraoperative Oxygenation and Lung Mechanics During One-Lung Ventilation: A Prospective Observational Study
Important dates
- Study start
- 2025
- Primary completion
- 2026
- Study completion
- 2026
- First posted
- Jan 8, 2026
- Registry last updated
- Jan 8, 2026
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.