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NCT Number: NCT03601104

Effects of Low Intensity, High Intensity Eccentric Resistance Training Associated With Blood Flow Restriction

Introduction: studies on resistance training of low intensity associated with blood flow restriction in recent years, although there are still gaps that can be explored in relation to their physiological phenomena when associated with eccentric training. In this way, from there the exploration becomes relevant the investigation of eccentric training associated to an RFS. Objective: To analyze and compare the effects of a high intensity and low intensity intensive resistance training associated with an RFS (TREAI-RFS and TREBI-RFS) with a high intensity eccentric resistance training without RFS (TREAI) in knee extensors. Method: The study will consist of 45 male participants, allocated from a stratified randomization into three groups: TREAI (n = 15), TREAI-RFS (n = 15) and TREBI-RFS (n = 15). Participants underwent a training program with a minimum of 40% without RFS, 80% with RFS and 40% with CVS of CVIM, 3 times a week, and the outcomes of muscle strength, muscle structure, power test and Endothelial growth will be assessed one week before, the fourth week and one week after the end of the training program. In addition, clinical markers of perception and recovery effort are investigated before and after a session. The graph used is descriptive and descriptive, as it is used as a model of analysis of variance for the analysis of replications without a two-factor scheme, which provides detailed information on how the measures are repeated, neither. A whole statistical analysis can reach the level of significance of 5%.

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Key information

Conditions

Exercise Behavior Motor Activity

Age range

18 year–35 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Franciele Marques Vanderlei

Presidente Prudente, São Paulo, 55, Brazil

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • male sex;
  • healthy;
  • aged between 18 and 35 years

Exclusion criteria

  • smokers;
  • alcoholics;
  • use drugs that influenced cardiac autonomic activity;
  • cardiovascular, metabolic or endocrine diseases.

Treatment and study plan

High intensity eccentric training

Other

High intensity eccentric training group with 80% of isometric peak torque.

High intensity eccentric training with BFR

Other

Eccentric high intensity training group with 80% of isometric peak torque associated with blood flow restriction (40% of absolute occlusion pressure).

Low intensity eccentric training with BFR

Other

Low intensity eccentric training group with 40% of isometric peak torque associated with blood flow restriction (40% of absolute occlusion pressure).

Low intensity eccentric training

Other

Low intensity eccentric training group with 40% of isometric peak torque

Primary outcomes

  1. Change in muscle strength torque peaks at dinamometer isokinetic

    Time frame: baseline, fourth week and one week after sixth week

    The isometric, eccentric and concentric torque peaks will be measured with an isokinetic dynamometer in order to evaluate the adaptations of knee extensor force to eccentric training.

  2. Change in muscular structure with ultrasonography

    Time frame: baseline, fourth week and one week after sixth week.

    Ultrasonographic imaging of the dominant lower limb will be captured to determine muscle thickness of the vastus lateralis (VL) and rectus femoris (RF) muscles.

  3. Change in Vascular Endothelial Growth Factor (VEGF)

    Time frame: baseline, fourth week and one week after sixth week.

    For the analysis of the concentration of endothelial growth factor (VEGF) will be collected 10 ml of blood sample. The plasma of this sample will be stored at -80 ° C for further analysis.

  4. Change in muscle power test

    Time frame: baseline, fourth week and one week after sixth week.

    The strength and muscle power tests will be performed on a vertical squat with a guided bar.

Secondary outcomes

  1. Pain threshold

    Time frame: Assessed at baseline, 4th week, and 6th week.

    To assess the pain threshold, the pressure algometer will be applied at five specific locations on the quadriceps.

  2. Analog Visual Scale

    Time frame: Assessed at baseline, 4th week, and 6th week.

    The subjective evaluation of pain will be obtained through the Visual Analogue Scale (EVA), graded from 0 to 10, with zero being the total absence of pain and 10 the maximum level of pain supported by the participant.

  3. Perceived Effort Scale (Borg)

    Time frame: Assessed at baseline, 4th week, and 6th week.

    The degree of subjective exertion reported by the participants in relation to the lower limbs will be analyzed by Borg's scale of perception of effort of 6 to 20 points, 6 being "very easy" and 20 being "exhaustive."

  4. Recovery Perception Scale

    Time frame: Assessed at baseline, 4th week, and 6th week.

    The perception of recovery of the lower limb submitted to the eccentric exercise protocol will be evaluated by means of a 10-point Likert Scale, where 1 indicates "not recovered" and 10 "fully recovered".

Sponsors and collaborators

Lead sponsor

Paulista University

Other

Registry information

Official study title

Effects of Low Intensity, High Intensity Eccentric Resistance Training Associated With Blood Flow Restriction: a Randomized Controlled Trial

Acronym: oclusion

Important dates

Study start
2019
Primary completion
2019
Study completion
2020
First posted
Jul 26, 2018
Registry last updated
Mar 9, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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