Skip to main content
OpenTrials
Completed

NCT Number: NCT04050267

Effects of Low Concentrations of Nitrous Oxide

The aim of the study is to test the effects of low concentrations of nitrous oxide on cognitive functions and reaction time in human.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Nitrous Oxide Poisoning

Age range

18 year–30 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Czech Technical University

Prague, Czechia

About this study

Nitrous oxide is a widely used gas in medicine, in standard concentrations above 50%. Its favourable physical properties and easy detectability by anaesthetic gas analysors predispose nitrous oxide to become a possible "tracing gas" for leak detection in experiments in which modified breathing system are in use. In these breathing experiments, the inspired concentrations of nitrous oxide would be well below the anaesthetic/analgesic concentrations. The aim of this study is to investigate the effects of these low concentrations of nitrous oxide (5, 7, 10, 12, 15, 20 %), compared to placebo (air, 0% nitrous oxide). The cognitive functions are tested using Digit Symbol Substitution Test, Reaction Time and Visual Analogue Scale.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • healthy volunteers from the Czech Technical University

Exclusion criteria

  • pregnancy
  • allergy to nitrous oxide
  • severe asthma or other severe respiratory conditions
  • severe cardiovascular conditions

Treatment and study plan

Nitrous Oxide

Drug

Breathing nitrous oxide, concentrations 5, 7, 10, 12, 15, 20 % in air with 21 % oxygen, in random order.

Placebo - air

Other

Breathing air with 21 % oxygen, no nitrous oxide.

Primary outcomes

  1. Cognitive test results

    Time frame: Through study completion, an average of 1 year

    The results of cognitive test performed during inhalation of defined concentration of nitrous oxide. Cognitive tests: Digit Symbol Substitution Test (DSST).

  2. Reaction Time

    Time frame: Through study completion, an average of 1 year

    The results of reaction time test performed during inhalation of defined concentration of nitrous oxide. Reaction Time (in seconds) using a computer-based test.

Sponsors and collaborators

Lead sponsor

Czech Technical University in Prague

Other

Registry information

Official study title

Effects of Low Concentrations of Nitrous Oxide on Cognitive Functions and Reaction Time

Important dates

Study start
2019
Primary completion
2019
Study completion
2019
First posted
Aug 8, 2019
Registry last updated
Aug 9, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.