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Completed

NCT Number: NCT03098433

Effects of Liothyronine on Energy Expenditure and Cardiovascular Function

This study will assess the short term effects of a single dose of liothyronine on the cardiovascular system and energy expenditure

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Key information

Conditions

Healthy

Age range

18 year–45 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 1 / Phase 2

Primary location

Virginia Commonwealth University

Richmond, Virginia, 23298, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • BMI >20<30 kg/m2
  • TSH >0.5<5.0 mcIU/mL
  • Negative TPO antibodies

Exclusion criteria

  • Pregnancy
  • Use of prescription drugs
  • Diabetes mellitus
  • Coronary artery disease
  • Hypertension
  • Anemia
  • Renal insufficiency
  • Liver disease or ALT >2.5 x the upper laboratory reference limit

Treatment and study plan

liothyronine

Drug

Single dose

Levothyroxine

Drug

Active comparator

Placebos

Drug

Placebo

Primary outcomes

  1. Cardiac Output

    Time frame: five hours

    Cardiac output measured by Echocaridogram, Difference in Stroke Volume Pre- and Post- Drug Administration

Secondary outcomes

  1. Energy Expenditure

    Time frame: five hours

    Energy expenditure measured by Whole-Room Indirect Calorimeter, Difference in energy Expenditure Pre- and Post- Drug Administration Kcal

Sponsors and collaborators

Lead sponsor

Virginia Commonwealth University

Other

Registry information

Important dates

Study start
2017
Primary completion
2019
Study completion
2019
First posted
Mar 31, 2017
Registry last updated
Mar 26, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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