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Completed

NCT Number: NCT00177099

Effects of Ligands on Human Hair Follicles Grafted Onto SCID Mice

The purpose of this study is to determine if immunophilin ligands may have the potential to reverse hair loss.

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Key information

Conditions

Alopecia Hair Diseases Hypotrichosis Pathological Conditions, Anatomical Pathological Conditions, Signs and Symptoms Skin Diseases Skin and Connective Tissue Diseases

Age range

18 year–65 year

Sex eligibility

Male

Study type

Interventional

Phase

Phase 1

Primary location

University of Minnesota

Minneapolis, Minnesota, 55455, United States

About this study

Preliminary experiments in C57BL/6J mice showed that immunophilin ligand FK506 and its non-immunosuppressive analogs, GP11046 and GP11511 were capable of promoting telogen to anagen transition. Since GP11046 and GP11511 possess the neurotrophic properties of FK506 without its immunosuppressant capability, the neural action of these immunophilin ligands may play an important role in the hair cycle. This finding has significant clinical implications in that immunophilin ligands may have the potential to reverse alopecia. To further investigate this possibility we propose to explore the response of transplanted miniaturized scalp hair follicles to topically applied immunophilin ligands.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy men ages 18-65 with Hamilton type IV or V alopecia

Exclusion criteria

  • Individuals who do not meet the inclusion criteria.

Treatment and study plan

FK506, GP11046, GP11511

Drug

Primary outcomes

  1. The average number of terminal hairs per graft will be compared between the control and the treated group.

Secondary outcomes

  1. The number of follicles in anagen, catagen and telogen per graft will be averaged for each group. The results will be compared between the control and the treated groups.

Sponsors and collaborators

Lead sponsor

Hordinsky, Maria K., MD

Indiv

Registry information

Official study title

Neurotrophic Effects of Immunophilin Ligands on Human Hair Follicles Grafted Onto Service Combined Immunodeficient (SCID) Mice

Important dates

Study start
2003
Study completion
2004
First posted
Sep 15, 2005
Registry last updated
Nov 13, 2006

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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