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Completed

NCT Number: NCT02426606

Effects of Lentil Consumption on Post-prandial Blood Glucose and Insulin

The purpose of this study is to assess the effects of consuming various lentil varieties in mixed-meals (containing either white rice or white potato) on post-prandial blood glucose and insulin as compared to white rice or white potato alone.

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Key information

Age range

18 year–40 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Human Nutraceutical Research Unit

Guelph, Ontario, N1G 2W1, Canada

About this study

Eligible participants will undergo a total of 6 study visits. During each visit, a fasted blood sample will be taken by fingerprick, and approximately 500µL of blood will be dripped into a collection tube. The participant will then consume a meal of either: white bread, white rice (or white potato), or white rice with lentils (or white potato with lentils). White bread will be consumed on the first study visit and the rest of the meals will take place in random order in the visits following. Each meal will provide a total of 50g available carbohydrate. Six more blood samples will be taken by fingerprick at 15, 30, 45, 60, 90 and 120 minutes after the beginning of the meal.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy men and women
  • Age 18-40 years
  • BMI 20-30 kg/m2

Exclusion criteria

  • Tobacco use
  • Pregnant or breastfeeding
  • Fasting blood glucose ≥ 7.0 mmol/L
  • Any major medical condition including a history of AIDS or hepatitis
  • Medical or surgical event requiring hospitalization within 3 months of randomization
  • Any medications except a stable dose (3 months) of oral contraceptives, blood pressure or statin medications
  • Blood pressure >140/90 mm Hg
  • Natural health products (NHPs) used for glycemic control
  • Probiotic supplements
  • Dietary fibre supplements
  • Consumption of >4 servings of pulses per week
  • Food allergy or non-food life threatening allergy
  • Shift workers
  • Alcohol consumption >14 drinks/week or >4 drinks/sitting
  • Recent or intended significant weight loss or gain (>4 kg in previous 3 months)
  • Elite athletes

Treatment and study plan

Various lentil varieties (varying in slow digested starch content)

Other

Randomized, cross-over block design.

Comparison of glycemic and insulinemic responses following meals composed of:

  • white rice or white rice combined with 1 of 3 different lentil varieties or
  • white potato or white potato combined with 1 of 3 different lentil varieties

Participants with be assigned to either the white rice or white potato group. Meals will provide 50g available carbohydrate (AC). In meals containing lentils, whole cooked lentils will provide 25g AC either white rice or white potato will provide 25g AC.

Meals will be randomly consumed across 6 study visits, with 2 white bread control meals (one of which will take place on the first visit).

Primary outcomes

  1. Postprandial blood glucose

    Time frame: Acute- 2 hours following meal

    Different meals will be consumed on separate occasions over 3-6 week period.

  2. Postprandial blood insulin

    Time frame: Acute- 2 hours following meal

    Different meals will be consumed on separate occasions over 3-6 week period.

Sponsors and collaborators

Lead sponsor

University of Guelph

Other

Collaborators

  • Agriculture and Agri-Food Canada
  • Pulse Canada
  • Saskatchewan Pulse Growers

Registry information

Official study title

The Love of Lentils (LoL) Study: The Effects of Acute Consumption of Common Lentil Varieties on Post-prandial Blood Glucose and Insulin Levels in Healthy Adult

Important dates

Study start
2014
Primary completion
2016
Study completion
2016
First posted
Apr 27, 2015
Registry last updated
Oct 25, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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