Effects of Lactobacillus Delbruckii Lactis DN111244 Fermented Milk Consumption on Plasma Lipids Levels in Hypercholesterolaemic Adults

Inclusion criteria

• male and female aged 18-75 years;
• BMI between 19 and 30 kg/m2,
• LDL-cholesterol plasma level between 130 mg/dL to 190 mg/dL (bounds included) with or without statin monotherapy,
• stabilized hypercholesterolemia (since more than 3 months),
• accepting to follow the dietary recommendations advisable for hypercholesterolemic patient (NCEP-ATP III guidelines),
• used to consume dairy products,
• for female: effective contraceptive methods used,
• agreeing to a written informed consent

Exclusion criteria

• plasma triglycerides (TG) levels > 350 mg/dL (4 mmol//L),
• any cardiovascular event (infarction, angina, surgical or endocoronary intervention, stroke, peripheral arteriosclerosis, etc) in the last 6 months,
• known allergy or hypersensitivity to milk proteins,
• systemic treatment or topical treatment likely to interfere with evaluation of the study parameters,
• subject currently involved in a clinical trial or in an exclusion period following participation in another clinical tria,
• subject in a situation which in the investigator's opinion could interfere with optimal participation in the present study or could constitute a special risk for the subject,
• diabetic subjects (type I and type II),
• any kind of disease likely to interfere with the evaluation of efficiency or safety of the product,
• for female subject: pregnancy, breast feeding or intention to become pregnant during the study,
• for female subject: subject likely to change her contraceptive method during the study,
• active heavy cigarette smokers (reported more than 20 cigarettes / day),
• subjects who are actively participating in a weight loss program or have participated in a weight loss program in the three months prior to screening for the study