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Completed

NCT Number: NCT00687518

Effects of Intravenous Injection of Erythropoietin on Hepcidin Pharmacokinetics in Healthy Volunteers

The aim of this study is to measure the variations of serum and urinary hepcidin levels following a single intravenous injection of erythropoietin in healthy volunteers. Hepcidin is a major regulator of iron homeostasis. It acts by binding on ferroportin, and limits cellular efflux of iron through enterocytes and macrophages. Anemia and hypoxia are known to modulate hepcidin synthesis. In these situations, erythropoietin synthesis is increased, so it can be postulated that erythropoietin could modulate hepcidin synthesis.

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Key information

Conditions

Iron Metabolism Disorders Metabolic Diseases Nutritional and Metabolic Diseases

Age range

18 year–40 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Unité d'Investigation Clinique - Centre d'Investigation Clinique - Hôpital de Pontchaillou

Rennes, 35033, France

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • healthy volunteers
  • male aged 18 - 30
  • normal routine laboratory values
  • normal ECG
  • normal iron status

Exclusion criteria

  • C282Y mutation of the HFE gene
  • alcohol or tobacco consumption

Treatment and study plan

Erythropoietin

Drug

Intravenous injection of 50 U/kg of erythropoietin

Other names: Neorecormon®

Placebo

Drug

Intravenous injection of equivalent volume of saline serum

Other names: NaCl 0,9%

Primary outcomes

  1. serum hepcidin levels

    Time frame: over 24 hours

Secondary outcomes

  1. urinary hepcidin levels

    Time frame: over 24 hours

  2. serum iron and ferritin levels

    Time frame: over 24 hours

Sponsors and collaborators

Lead sponsor

Rennes University Hospital

Other

Registry information

Acronym: HEPEPO

Important dates

Study start
2008
Primary completion
2008
Study completion
2008
First posted
May 30, 2008
Registry last updated
Jun 12, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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