Effects of Intrathecal Local Anesthetics on Left Ventricular Global Longitudinal Strain

The objective of this study is to assess the effects of intrathecal local anesthetics on left ventricular global longitudinal strain (LVGLS) using transthoracic echocardiography (TTE).

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Key information

Conditions

Left Ventricular Dysfunction Cardiovascular Diseases Global Cardiac Wall Motion Dysfunction Heart Diseases Spinal Anesthetics Causing Adverse Effects in Therapeutic Use Sprains and Strains Ventricular Dysfunction Ventricular Dysfunction, Left Wounds and Injuries

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Milton S. Hershey Medical Center

Hershey, Pennsylvania, 17033, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Adult patients undergoing elective knee and hip replacements under spinal anesthesia

Exclusion criteria

Patients who do not wish to consent
Patients with contraindications to TTE
Patients with reduced left ventricular systolic function as defined by LV ejection fraction < 50% on pre-operative echocardiography
Patients with body mass index greater than 40
Non-English-speaking subjects
Cognitively impaired adults

Treatment and study plan

Intrathecal local anesthesia

Drug

Administration of local anesthetic into intrathecal space to achieve surgical anesthesia

Other names: Spinal anesthesia

Primary outcomes

Left Ventricular Global Longitudinal Strain

Time frame: 5 minutes

Secondary outcomes

Left Ventricular Ejection Fraction

Time frame: 5 minutes

Sponsors and collaborators

Lead sponsor

Milton S. Hershey Medical Center

Other

Registry information

Important dates

Study start: 2023
Primary completion: 2023
Study completion: 2023
First posted: Dec 14, 2022
Registry last updated: Nov 24, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed