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Completed

NCT Number: NCT03428906

Effects of Intranasal Oxytocin on Functional Brain Network in Resting-state and Tasks

To investigate whether and how intranasal oxytocin of 8IU treatment will alter the topology of functional brain network in resting-state and multiple tasks in healthy males.

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Key information

Conditions

Healthy

Age range

18 year–30 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

School of Brain and Cognitive Sciences, Beijing Nornal University

Beijing, Beijing Municipality, 100875, China

About this study

In a randomized, double-blind, cross-over, placebo controlled design, healthy male volunteers receive intranasal oxytocin or placebo prior to functional magnetic resonance imaging.Subjects will then go through a decision making task, a emotion judgement task and an eight-minute resting-state scan in MRI scanner to investigate whether and how intranasal oxytocin alter the topology of functional brain network in resting-state and multiple tasks in healthy males. State anxiety and mood are measured before and after experiment as covariates to be controlled.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • healthy subjects without past or current psychiatric or neurological disorders

Exclusion criteria

  • with MRI Contraindications

Treatment and study plan

Oxytocin

Drug

intranasally administrated

Placebo

Drug

intranasally administrated

Other names: Saline

Primary outcomes

  1. Functional network organization alterations in brain under resting state fMRI after drug administration

    Time frame: 70~85 minutes after drug administration

    Using seed-based and network level functional connectivity analysis, as well as graph theory analysis , functional network organization in brain under eight minutes resting state will be detected and compared between oxytocin and placebo group.

  2. Behavior,brain activities and representation patterns in the emotional judgement task after drug administration

    Time frame: 60~75 minutes after drug administration

    Friend or Foe Task is used to measure the verbal versus nonverbal emotional judgement of subjects. Both the response of subjects and the brain activity are recorded in the task. How oxytocin influences the relationship between subjects' behavior and representation pattern of emotional judgement will be investigated through RSA(representation similarity analysis) of brain pattern.

  3. Behavior, dynamics brain activities and networks in the model-based decision making task after drug administration

    Time frame: 35~60 minutes after drug administration

    Two-Stage Decision Making Task is used to measure the model-based and model-free decision making process of subjects. The degree of model-based will be calculated by Computational modelling of Subjects' decision making process, and entering as modulation parameter in the OT effect on dynamic brain seed-based and network-based connectivity pattern.

  4. Relationship of functional network organization in brain across resting state and task-based fMRI after drug administration

    Time frame: 60~85 minutes after drug administration

    The functional brain activity in resting state, emotional judgement and decision making task will be compared. Both the functional segregation and integration will be measured using graph theory and network connectivity analysis to discover the OT effect on brain network organization across multiple cognitive states.

Sponsors and collaborators

Lead sponsor

Beijing Normal University

Other

Registry information

Official study title

Effects of Intranasal Oxytocin on Male's Functional Brain Network in Resting-state and Tasks

Important dates

Study start
2016
Primary completion
2017
Study completion
2017
First posted
Feb 12, 2018
Registry last updated
Feb 12, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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