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Completed

NCT Number: NCT03801486

Effects of Incorporating Sprouted and Non-sprouted Chickpea Flour in Pasta Products Analyzed in Vivo Flow-mediated Dilation

The investigators examined the effects on post-digestion brachial artery flow mediated dilation (FMD) and in vitro antioxidant capacity of 40% semolina flour replacement with sprouted chickpea flour.

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Key information

Age range

18 year–50 year

Sex eligibility

All sexes

Study type

Observational

About this study

The purpose of the current study was to examine in-vitro and in-vivo effects of replacing 40% of semolina flour with sprouted chickpea flour for the use in pasta. Antioxidant capacity in-vitro was measured by Trolox Equivalent Antioxidant Capacity. Brachial artery flow-mediated dilation, a test of in-vivo endothelial function, was performed for assessment of effects on post-digestion endothelial function. The investigators hypothesized that FMD would be higher after consuming 40% of semolina flour with sprouted chickpea flour pasta vs. 100% of semolina flour pasta.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • healthy adult

Exclusion criteria

  • have diabetes mellitus, kidney disease, a history of cancer, cardiac issues, pulmonary disease, history of a stroke, obesity (for most people this means a body mass index greater than 30), or any life threatening chronic conditions.
  • food allergies relevant to wheat, gluten, chickpea, and pasta sauce.
  • are currently being treated for infectious mononucleosis, hepatitis, pneumonia, or other infectious diseases.
  • are unable or unwilling to refrain from recreational drug (marijuana, cocaine, etc.) or alcohol use during the 24 hours prior to your exercise session.
  • use nicotine products, or non-contraceptive hormonal therapy (birth control is okay).
  • are pregnant or trying to become pregnant.

Treatment and study plan

Experimental: Sprouted Chickpea Flour

Other

255g of pasta with 40% sprouted chickpea flour and 60% semolina flour (SCF40) with butter.

Other names: SCF40

Control: Semolina Flour

Other

255g of pasta with 100% semolina flour (SEM100) with butter.

Other names: SEM100

Primary outcomes

  1. Post-digestion flow mediated dilation

    Time frame: Two hours following meal

    Post meal

Sponsors and collaborators

Lead sponsor

Montclair State University

Other

Registry information

Official study title

The Effects of Incorporating Sprouted and Non-sprouted Chickpea Flour in Pasta Products Analyzed in Vivo Flow-mediated Dilation

Important dates

Study start
2016
Primary completion
2017
Study completion
2017
First posted
Jan 11, 2019
Registry last updated
Oct 30, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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