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NCT Number: NCT07559344

Effects of Hot Baths Prior or After a Damaging Protocol on Muscle Function and HSP70 Expression

Muscle lengthening contractions lead to physiological responses such as strength loss, soreness, immune cell infiltration, and CK production, along with elevated heat shock proteins (HSPs), which protect and regenerate cells. Passive heating before or after exercise can aid in recovery by restoring strength and reducing soreness, requiring a core temperature of over 38.5°C for 20 minutes to be effective. Studies show that combined mechanical and thermal stress induces a cumulative HSP response, enhancing cellular protection. Thermal stress alone peaks at 16- 24 hours, whereas mechanical stress shows a biphasic response, with peaks at 3-6 hours and around 39 hours. Thus, combining heat with exercise could optimize HSP production, improving recovery by increasing and accelerating the HSP response. However, more research is needed to determine the best timing for thermal stress in human applications, especially in sports and therapy contexts.

This study aimed to compare the effects of hot-water immersion administered before versus after muscle-lengthening exercise on muscle function and HSP70 expression in healthy young athletes.

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Key information

Conditions

Recovery Cumulative Response HSP70 Heat Stress Heat Stress Disorders Hot-water Immersion Mechanical Stress Wounds and Injuries

Age range

19 year–25 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

CHRU Amiens

Amiens, 80054, France

Location status: Recruiting

Location contact

Yannis Hamidou, MD

CONTACT

[email protected]

33+3 22 66 82 48

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Sex: Healthy, athletic men practicing track and field (10 to 12 hours/week)
  • Age: 19 to 25 years old
  • Social security coverage
  • Signed informed consent

Exclusion criteria

  • Age over 26 years
  • Low level of physical activity (less than 8 hours per week)
  • Recent sprain (type 1, 2, or 3) or ligament rupture in the lower limb (within the last 8 months)
  • Exposure to an altitude of 2500m within 15 days prior to the protocol
  • Presence of arterial hypotension:
  • Systolic blood pressure below 90 mmHg
  • Diastolic blood pressure below 60 mmHg
  • A drop in systolic blood pressure greater than 20 mmHg upon moving from a lying to a standing position.
  • A drop in diastolic blood pressure greater than 10 mmHg upon moving from a lying to a standing position.
  • Presence of dizziness, lightheadedness, or blurred vision upon moving from a lying to a standing position.
  • Participant under guardianship/conservatorship or deprived of liberty.

Treatment and study plan

immersion

Other

Immersion lasted 40 minutes with the goal of reaching a core temperature of 38.5°C in the heat-stress groups

NIRS

Other

NIRS

isokinetic dynamometer

Other

isokinetic dynamometer

pressure algometer

Other

pressure algometer

Hokanson armband

Other

Hokanson armband

Primary outcomes

  1. HSP 70 concentration

    Time frame: 1 year

    HSP 70 concentration in third groups

Secondary outcomes

  1. gastro-intestinal temperature

    Time frame: 1 year

  2. muscle temperature

    Time frame: 1 year

Study contacts

Contact information is provided by the study sponsor or research team.

Yannis Hamidou, MD

CONTACT

[email protected]

33+3 22 66 82 48

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Universitaire, Amiens

Other

Collaborators

  • CH CORBIE

Registry information

Acronym: Prehotemp

Important dates

Study start
2026
Primary completion
2027
Study completion
2027
First posted
Apr 30, 2026
Registry last updated
Apr 30, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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