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Completed

NCT Number: NCT06292442

Effects of HIIT on Muscle Strength, Atrophy and Aerobic Capacity in Stroke Patients.

To determine the effects of High-Intensity Interval Training on muscle strength, atrophy, and aerobic capacity in stroke patients.

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Key information

Conditions

Stroke Atrophy Brain Diseases Cardiovascular Diseases Central Nervous System Diseases Cerebrovascular Disorders Muscular Atrophy Nervous System Diseases Neurologic Manifestations Neuromuscular Manifestations Pathological Conditions, Anatomical Pathological Conditions, Signs and Symptoms Signs and Symptoms Vascular Diseases

Age range

40 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Jinnah Hospital, Lahore

Lahore, Punjab Province, 54000, Pakistan

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Both males and females were included
  • aged 40-60 years
  • Chronic stroke patients who experienced a first-ever ischemic stroke
  • Stable cardiovascular condition (American Heart Association class B)
  • Physician clearance to participate in a 4-week HIIT program
  • No prior structured exercise in the last 3 months
  • Ability to walk 10 m over ground with or without assistive devices
  • Patients who scored >24/30 on MMSE (Mini-Mental State Examination)

Exclusion criteria

  • Patients who were hospitalized for cardiac or pulmonary disease within the past 3 months
  • Patients who had implanted pacemaker or defibrillator
  • Patients having conditions where VO2peak assessment is contraindicated, such as uncontrolled hypertension(>180/100), severe aortic stenosis, acute myocarditis, recent myocardial infarction, or other acute cardiovascular events within the past three months, were excluded from the study
  • Patients with severe lower limb spasticity (Ashworth Scale scores >2 of 4 for knee flexion, knee extension, or ankle dorsiflexion)
  • Pregnant females
  • Previous exposure to fast treadmill walking in the past year

Treatment and study plan

Traditional Physical therapy

Other

This group received conventional physical therapy treatment including Range of Motion (ROM) exercises for the affected hip, knee, and ankle joints, as well as stretching exercises for tight lower limb muscles, administered 3 times per week for 4 weeks, with each session lasting approximately 20-30 minutes.

High Intensity Interval Training

Other

This group received High Intensity interval training along with conventional treatment for lower limb muscles, performed 3 times per week fr 4 weeks.

Primary outcomes

  1. Muscle strength

    Time frame: 4th week

    Manual Muscle Testing is a test that is used to assess muscle strength.

  2. Muscle Atrophy

    Time frame: 4th week

    Measuring tape is used to measure the calf circumference to measure the atrophy, muscle size over time.

  3. 6-Minute Walk Test (6MWT)

    Time frame: 4th week

    6-Minute Walk Test (6MWT) used to measure Functional capacity, aerobic fitness and endurance.

  4. Aerobic Capacity

    Time frame: 4th week

    Harvard Step Test is used to measure Functional capacity, aerobic fitness and endurance.

Secondary outcomes

  1. Fastest Gait Speed

    Time frame: 4th week

    10-Meter Walk Test is a test used for assessing gait speed, monitoring rehabilitation progress, functional assessment, fall risk assessment, and research purposes.

Sponsors and collaborators

Lead sponsor

Riphah International University

Other

Registry information

Official study title

Effects of High-Intensity Interval Training on Muscle Strength, Atrophy and Aerobic Capacity in Stroke Patients.

Important dates

Study start
2023
Primary completion
2023
Study completion
2023
First posted
Mar 5, 2024
Registry last updated
Mar 5, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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