Effects of Hemoperitoneum Driven Carbon Monoxide on Post-Traumatic Stability and Platelet Aggregation

Our objective is to determine whether or not the presence of hemoperitoneum in trauma patients is associated with increased Carbon Monoxide (CO) formation, and to determine if elevated Carbon Monoxide levels are associated with cardiovascular depression, impaired platelet aggregation, and/or multiple organ failure.

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Key information

Conditions

Hemoperitoneum Digestive System Diseases Hemorrhage Pathologic Processes Pathological Conditions, Signs and Symptoms Peritoneal Diseases

Age range

18 year and older

Sex eligibility

Female

Study type

Observational

Primary location

University Hospital

San Antonio, Texas, 78229, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Hospitalized males 18 years of age or older,
Diagnosis of isolated blunt OR blunt and penetrating trauma,
Admitted or expecting to be admitted to the Intensive Care Unit,
On mechanical ventilation, and
Written informed consent obtained

Exclusion criteria

Female gender, (Females will be excluded from this study as the menstrual cycle and other estrogen variations are known to be associated with cyclic changes in CO production adding a potential confounder to the interpretations of our findings.)
Diagnosis of isolated penetrating trauma,
Acute hemothorax or pneumothorax,
Treatment with antiaggregants (ASA, clopidogrel, aggrenox or ticlopidine),
Enrollment in another research study,
Prisoners,
Inability to perform CO measurement within 96 hours after hospital admission.

Treatment and study plan

expired air

Procedure

collection of expired air from ventilator

Primary outcomes

•Establish a method for reliably measuring CO excretion in patients.

Time frame: 96 hours

Sponsors and collaborators

Lead sponsor

The University of Texas Health Science Center at San Antonio

Other

Registry information

Official study title

Effects of Hemoperitoneum Driven Carbon Monoxide on Post-Traumatic Stability

Important dates

Study start: 2009
Primary completion: 2011
Study completion: 2011
First posted: May 8, 2012
Registry last updated: May 14, 2012

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed