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Completed

NCT Number: NCT00846950

Effects of H1-Antagonist on Cognition

The purpose of this study is to determine whether histamine is involved in memory and specific processes in human cognition.

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Key information

Conditions

Cognition

Age range

18 year–45 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Faculty of Psychology and Neuroscience, Maastricht University

Maastricht, Limburg, 6229 ER, Netherlands

About this study

The neurotransmitter histamine appears to be involved in human cognitive performance. However, the exact role is very unclear. The role it plays in memory performance is highly disputed, as animal studies show decreased performance when the H1-receptor is blocked in the central nervous system while such findings in humans is scarce. To clarify the role of histamine in human memory and different processes in cognition, the effects of an H1-antagonist (dexchlorpheniramine) on memory, alertness and sensory and motor processes are measured. The study will be conducted according to a within subject cross-over design using healthy volunteers.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy as determined by a physician

Exclusion criteria

  • present or history of any neurological of psychiatric disease
  • present or history of any substance abuse

Treatment and study plan

dexchlorpheniramine, lorazepam

Drug

Primary outcomes

  1. P300 latency and LRP onset latency

    Time frame: 1.5 hours after treatment

Secondary outcomes

  1. Words recalled

    Time frame: 1.5 hours after treatment

Sponsors and collaborators

Lead sponsor

Maastricht University Medical Center

Other

Registry information

Official study title

Effects of H1-Antagonist on Stages of Human Information Processing

Important dates

Study start
2006
Primary completion
2007
Study completion
2007
First posted
Feb 19, 2009
Registry last updated
Feb 19, 2009

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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