Effects of Gonadotropin Replacement Therapy on Metabolic Parameters in Patients With Hypogonadism

Effects of gonadotrophin replacement therapy Lipid Profile and Oxidative Stress Parameters of Patients with Idiopathic Hypogonadotropic Hypogonadism

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Key information

Conditions

Idiopathic Hypogonadotropic Hypogonadism

Age range

22 year–35 year

Sex eligibility

Male

Study type

Observational

About this study

30 male patients diagnosed with IHH and a control group of 20 healthy cases with similar age and BMI were included in the study. The levels of advanced oxidation protein products (AOPP), thiol, malondialdehyde (MDA), nitric oxide (NO) and 8-hydroxydeoxyguanosine (8-OHdG) and the levels of triglyceride (TG), total cholesterol (TC), high density lipoprotein (HDL-K), low density lipoprotein (LDL-K), Apolipoprotein A1 (ApoA1) and Apolipoprotein B100 (ApoB100) were measured before and after gonadotrophin therapy.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Serum testosterone concentration < 300ng/dL Absence of a pituitary or hypothalamic mass lesions, Presence of gonadotropin response to GnRH, -

Exclusion criteria

diabetes mellitus, arterial hypertension other hormone deficiencies

Treatment and study plan

human chorionic gonadotropin, human menopausal gonadotropin

Drug

drug for the treatment of male hypogonadism

Other names: Pregnyl ® Organon hCG 1500 IU, Merional ® ARIS 75 IU

Primary outcomes

oxidative stress after hCG and HMG treatment

Time frame: 2010-2012
HDL levels after hCG treatment

Time frame: 2010-2012
total cholesterole levels after hCG treatment

Time frame: 2010-2012

Sponsors and collaborators

Lead sponsor

Gulhane School of Medicine

Other

Registry information

Official study title

Lipid Profile and Oxidative Stress Parameters of Patients With Idiopathic Hypogonadotropic Hypogonadism and the Change of These Parameters With Gonadotropin Replacement Therapy

Important dates

Study start: 2010
Primary completion: 2012
Study completion: 2012
First posted: Apr 5, 2016
Registry last updated: Apr 13, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed