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Completed

NCT Number: NCT01610986

Effects of Glucose-fructose Drinks During Training on Lactate Transport

The purpose of this study is to determine whether glucose-fructose intake during training increases lactate transport and oxidation and improve endurance performance.

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Key information

Conditions

Normal Physiology on Healthy Subjects Behavior Motor Activity

Age range

18 year–30 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

University of Lausanne

Lausanne, Canton of Vaud, 1005, Switzerland

About this study

The study will enroll 24 healthy male volunteers. After baseline assessment of lactate transport and endurance performance, subjects will be randomized to either a 3-week intervention arm in which they will train with glucose-fructose intake during training, or to a control arm (water during training). After this 3-week intervention, lactate transport and endurance performance will be assessed again.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • healthy
  • age between 18 and 30 years
  • sedentary
  • BMI between 19 and 25
  • blood pressure lower than 140/90 mmHg

Exclusion criteria

  • smoking
  • consumption of more than 10g alcohol per day
  • cardiovascular history
  • electrographic abnormalities at rest
  • consumption of more than one can of soda per day or more than 60g sugars per day
  • any current drug treatment
  • consumption of drugs or illicit substances
  • diabetes mellitus
  • vegetarian
  • food intolerance
  • blood donation or participation to another study <3 months before study inclusion

Treatment and study plan

Glucose-fructose

Dietary Supplement

0.8 g/h glucose and 0.5 g/h fructose during training

Water

Dietary Supplement

Only water intake during training

Primary outcomes

  1. Change in lactate transport

    Time frame: At baseline (before training) and after the 3-week training protocol

    Measurement of lactate production, utilization, oxidation and clearance during a 90 min cycling exercise at 50% VO2 max (measured with 13C-lactate)

Secondary outcomes

  1. Change in muscle monocarboxylate transporters (MCTs) expression and protein content

    Time frame: At baseline (before training) and after the 3-week training protocol

    MCTs expression (mRNA) and protein content after muscle biopsy

Sponsors and collaborators

Lead sponsor

University of Lausanne

Other

Collaborators

  • Centre Hospitalier Universitaire Vaudois

Registry information

Official study title

Effects of Glucose-fructose Drinks During Training on Lactate Transport and Oxidation and on Endurance Performance

Acronym: LactEx

Important dates

Study start
2012
Primary completion
2014
Study completion
2014
First posted
Jun 4, 2012
Registry last updated
Jun 4, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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