Effects of Glucagon Like Peptide 1 (GLP-1) Analogues on Fluid Intake

GLP-1 analogues are well known to stimulate glucose-induced insulin secretion and to reduce energy intake. Recent findings from animal and human studies suggest a role of GLP-1 in regulating water and salt homeostasis. GLP-1 has been shown to reduce fluid intake after an oral salt load or during a meal - pointing to a hypodipsic effect. The aim of this study is to elucidate whether these putative hypodipsic properties of GLP-1 analogues reduce fluid intake in healthy volunteers compared to placebo assessed during an evaluation visit of 8 hours.

Inclusion criteria

• Age 18 to 65 years

Exclusion criteria

• Known or probable central or nephrogenic Diabetes insipidus, based on patient's history
• Polyuria secondary to diabetes mellitus, hypokalemia, hypercalcemia
• Primary Polydipsia, defined as more than 4 liters fluid intake per day
• BMI <18 or >30kg/m2
• Pregnancy
• Previous treatment with GLP-1 agonists within the last 3 month
• History of pancreatitis
• Severe renal insufficiency (eGFR (CKD EPI) <30 ml/min/1,73 m2)
• Cancer