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Completed

NCT Number: NCT03712150

Effects of Gene Polymorphism After Transcranial Cranial Direct Current Stimulation on the Corticobulbar Excitability

This study aims to examine the effects of transcranial direct current stimulation at corticobulbar excitability in individuals with different gene polymorphism.

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Key information

Conditions

Healthy

Age range

19 year–40 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Department of Rehabilitation Medicine, Bucheon-si, Bucheonshi, South Korea

Loading trial locations.

About this study

The effects of TDCS on corticobulbar excitability of the brain after inhibitory pre-conditioning will be compared in patients with different BDNF phenotypes

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age 19-40 years
  • Informed consent

Exclusion criteria

  • History of epilepsy
  • Presence of cardiac pacemaker
  • previous brain surgery
  • previous swallowing problems
  • current use of medication which acts on the central nervous system
  • presence of implanted metal intracranially

Treatment and study plan

tDCS

Device

application of optimised parameters of tDCS (anodal stimulation, 1.5 mA, 10 min) over the unconditioned hemisphere reverses the brain and behavioural consequences of inhibitory pre-conditioning

Primary outcomes

  1. Brain corticobulbar excitability

    Time frame: Immediately after single conditioning the brain

    Change of Brain corticobulbar excitability by motor evoked potentials

Secondary outcomes

  1. Tongue pressure measurement-

    Time frame: Immediate after single conditioning the brain

    Change of tongue pressure measurement by Intra oral pressure assessment

  2. Electrophysiological responses of swallowing -

    Time frame: Immediate after single conditioning the brain

    Change of Electrophysiological responses of swallowing - With the use of a laryngeal transducer, will measure the mylohyoid amplitude

Sponsors and collaborators

Lead sponsor

The Catholic University of Korea

Other

Registry information

Official study title

Role of Genetic Polymorphism in Neuroplasticity Involved in Dysphagia Recovery- Part 2

Important dates

Study start
2018
Primary completion
2019
Study completion
2019
First posted
Oct 19, 2018
Registry last updated
Nov 7, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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