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Completed

NCT Number: NCT00720655

Effects of Fatty and Lean Fish Intake on Cardiovascular Risk Factors in Subjects With Coronary Heart Disease

The aim of the study is to examine the effects of fatty fish and white (lean) fish on cardiovascular disease risk factor levels in subjects with established coronary heart disease using multiple medications. The main end points are blood pressure, serum lipids, inflammatory markers, arrhythmias and gene expression in peripheral mononuclear cells. The study design was a controlled, parallel study lasting 8 weeks with three diet groups: fatty fish, white fish and control group (lean pork, beef or chicken).

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Key information

Conditions

Blood Pressure Arrhythmia Arrhythmias, Cardiac Cardiovascular Diseases Coronary Disease Heart Diseases Inflammation Myocardial Ischemia Pathologic Processes Pathological Conditions, Signs and Symptoms Vascular Diseases

Age range

Up to 70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Kuopio

Kuopio, 70211, Finland

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • myocardial infarction or unstable ischemic attack
  • use of beta blockers
  • normal sinus rhythm
  • fasting serum triglyceride less or equal to 3.5 mmol/l
  • fasting serum cholesterol less or equal to 8 mmol/l
  • BMI 18.5-30 kg/m2
  • fasting plasma glucose less or equal to 7 mmol/l

Exclusion criteria

  • diabetes
  • use of other antiarrhythmic medications than beta blockers
  • atrial fibrillation
  • use of psychotropic medications
  • abnormal liver, thyroid or kidney function
  • inflammatory bowel disease
  • excessive use of alcohol
  • use of fish oil supplements or high habitual intake of fish

Treatment and study plan

Dietary Intervention

Other

Fatty fish at least 4 meals per week.

Primary outcomes

  1. gene expression in peripheral mononuclear blood cells, risk of arrhythmias, serum lipids and blood pressure

    Time frame: 8 week

Secondary outcomes

  1. inflammatory markers

    Time frame: 8 week

Sponsors and collaborators

Lead sponsor

University of Eastern Finland

Other

Collaborators

  • Kuopio University Hospital

Registry information

Important dates

Study start
2005
Primary completion
2006
First posted
Jul 23, 2008
Registry last updated
Jan 22, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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