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OpenTrials
Completed

NCT Number: NCT00817440

Effects of Fasting and Exercise on Insulin and GH Signaltransduction in Muscle and Fat

Hypothesis: under fasting there will primarily be an activation of growth hormone(GH) signalpathways and a inhibition of insulin signalpathways, and the opposite will happen under physical activity.

Primarily we will investigate markers for GH and insulin signaltransduction in muscle- and fat-biopsies after fasting for 72 hours and after 1 hour of ergometer-cycling at 65% Vo2max.

In addition to this we will investigate the effect of fasting and exercise on the velocity of carbamide synthesis, aminoacid rate of turnover and glucose rate of turnover.

Completed

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Key information

Conditions

Healthy

Age range

18 year–45 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Aarhus sygehus

Aarhus, Jylland, 8000, Denmark

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • healthy men
  • Body mass index (BMI) 20-26
  • age 18-45 years

Exclusion criteria

  • any kind of disease
  • any use of medicine

Treatment and study plan

Exercise

Other

1 hour ergometer cycling on 65% of Vo2max, and then the same as arm 1.

Fasting

Other

3 days of fasting and then the same as arm 1

Primary outcomes

  1. Growth hormone and insulin signal pathways

    Time frame: 30 min

Secondary outcomes

  1. aminoacid and glucose turnover

    Time frame: 4 hours

Sponsors and collaborators

Lead sponsor

University of Aarhus

Other

Registry information

Acronym: FEIGH

Important dates

Study start
2008
Primary completion
2009
First posted
Jan 6, 2009
Registry last updated
Jan 11, 2011

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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