Skip to main content
OpenTrials
Completed

NCT Number: NCT01884142

Effects of Exercise Training on Mechanoreflex and Metaboreflex Control in Heart Failure Patients

The investigators hypothesize that exercise training would improve the mechanoreflex and metaboreflex control in heart failure patients.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Heart Failure Cardiovascular Diseases Heart Diseases

Age range

30 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Heart Institute (InCor), University of Sao Paulo Medical School

São Paulo, 05403-904, Brazil

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients with systolic heart failure;
  • New York Heart Association (NYHA) class II-III;
  • Left ventricular ejection fraction less than 40%;
  • Peak Oxygen Consumption less than 20 ml/Kg/min;
  • Stable Clinical Status.

Exclusion criteria

  • Chronic Obstructive Pulmonary Disease;
  • Neuromuscular Diseases;
  • Orthopedic Diseases;
  • Neurologic Diseases;
  • Neoplastic Diseases;
  • Recent myocardial infarction or cardiac surgery (less than 6 months);
  • Unstable angina pectoris;
  • Atrial Fibrillation;
  • Pacemakers users;
  • Changing medication or hospital admission.

Treatment and study plan

Aerobic exercise training

Other

Primary outcomes

  1. Autonomic Control

    Time frame: 4 months

    Mechanoreceptors were activated by passive exercise and metaboreceptors by post-exercise circulatory arrest

  2. Muscular Evaluation

    Time frame: 4 months

    Muscular evaluation will be done by muscle gene expression

Secondary outcomes

  1. Functional Capacity

    Time frame: 4 months

    Functional Capacity will be determined by cardiopulmonary exercise testing

  2. Muscle Blood Flow

    Time frame: 4 months

    Forearm blood flow will be assessed by venous occlusion plethysmography

  3. Blood Pressure

    Time frame: 4 months

    Blood pressure will be monitored non-invasively

Sponsors and collaborators

Lead sponsor

University of Sao Paulo General Hospital

Other

Collaborators

  • Conselho Nacional de Desenvolvimento Científico e Tecnológico
  • Fundação de Amparo à Pesquisa do Estado de São Paulo

Registry information

Official study title

Effects of Exercise Training on Mechanoreflex and Metaboreflex Control of Muscle Sympathetic Nerve Activity in Heart Failure Patients

Important dates

Study start
2008
Primary completion
2012
Study completion
2014
First posted
Jun 21, 2013
Registry last updated
Apr 28, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.